BrainBiotic™ Brain Health Probiotics

Probiotics For Your Brain
Rated 5.0 out of 5
1 Review
$29.95
Recommended
Probiotics For Your Brain
Rated 5.0 out of 5
1 Review

Brainbiotic™ is premium blend of probiotic strains designed to support the gut - brain axis. Research suggests that the probiotic strains in Brainbiotic™ are associated with increased brain-derived neurotrophic factor (BDNF), memory enhancement, and relief of stress-related symptoms.†

  • Gut-Brain Axis Optimizer
  • Defeat Brain Fog
  • Memory Support
  • Stress Relief

For a limited time: Get a free container of Prebiotic+ when you order a 3-pack of Brainbiotic (30 or 90 ct)

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Gut-Brain Axis Optimizer

Gut-Brain Axis Optimizer

Defeat Brain Fog

Defeat Brain Fog

Memory Support

Memory Support

Stress Relief

Stress Relief

Ingredients

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Lacto P. offers robust probiotic support against inflammatory compounds associated with impaired memory and cognitive decline. The strain has also been shown to increase BDNF to support the health and growth of new brain cells.

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Daily use of this strain has been shown to support gut bacteria associated with positive mood states. The cultures accomplish this by relieving stress-related gut inflammation and increasing production of calming neurotransmitters in the gut to support a positive mood and relieve stress.

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This unique strain is known to increase levels of the all-star brain growth hormone, brain-derived neurotrophic factor (BDNF). Higher levels of BDNF are associated with increased intelligence, positive mood, productivity, memory, as well as a decreased risk of various neurodegenerative mental states.

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Daily use of this strain has been shown to support gut bacteria associated with positive mood states. The cultures accomplish this by relieving stress-related gut inflammation and increasing production of calming neurotransmitters in the gut to support a positive mood and relieve stress.

Lactobacillus Plantarum

2 billion CFU

Lacto P. offers robust probiotic support against inflammatory compounds associated with impaired memory and cognitive decline. The strain has also been shown to increase BDNF to support the health and growth of new brain cells.

Lactobacillus Helveticus

2.7 billion CFU

Daily use of this strain has been shown to support gut bacteria associated with positive mood states. The cultures accomplish this by relieving stress-related gut inflammation and increasing production of calming neurotransmitters in the gut to support a positive mood and relieve stress.

Lactobacillus Brevis

1 billion CFU

This unique strain is known to increase levels of the all-star brain growth hormone, brain-derived neurotrophic factor (BDNF). Higher levels of BDNF are associated with increased intelligence, positive mood, productivity, memory, as well as a decreased risk of various neurodegenerative mental states.

Bifidobacterium Longum

0.3 billion CFU

Daily use of this strain has been shown to support gut bacteria associated with positive mood states. The cultures accomplish this by relieving stress-related gut inflammation and increasing production of calming neurotransmitters in the gut to support a positive mood and relieve stress.

Suggested Use

Take 1-2 capsules per day, or as directed by a healthcare practitioner. 

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How It Works

The microbiome is essential to health, immune function, and plays a major role in the communication between the gut and the brain. Over the past few years scientists have begun to understand the importance of the microbiome in the context of brain function. Studies show that the gut-brain axis (gut-brain connection) is deeply linked with numerous aspects of cognition including mood, memory, and brain health. By targeting the gut-brain axis with key probiotic strains we’re able to activate a positive immune response in the brain while improving cognitive function at any stage of life.

Probiotics are the healthy microbes our gut needs to function at its best. Within the gut is a vast and diverse “rainforest” of hundreds of different bacterial organisms. Over the past 5 years over 4,000 studies have investigated the link between the health of the gut microbiome and the health of the human brain. We’ve long known the gut’s role in immune function and digestion, but only in recent years have scientists discovered the powerful connection between gut and mind. Of all the studies looking at the gut-brain axis, researchers have identified 4 key strains that have been proven to unlock benefits related to mood, memory, brain health, and higher level cognitive functions. 

With the probiotics found in Brainbiotic™ you can support your brain while supporting your gut at the sametime.

Lactobacillus Plantarum

L. Plantarum is a beneficial and versatile probiotic strain, able to survive stomach acid with ease, allowing it to reach the colon fully active and intact. Here, the probiotic strain is effective at maintaining, restoring, and balancing the gut microbiota.

Studies have shown that L. Plantarum can support long-term memory by increasing levels of the all-star brain growth hormone, brain-derived neurotrophic factor (BDNF).  The culture has also been shown to improve cognitive abilities in rats by lowering pressure and exerting neuroprotective properties in brain cells. [1]

Regular consumption of L. Plantarum may also reduce anxiety. The strain was found to increase levels of dopamine and serotonin while reducing anxiety symptoms, depressive symptoms, and inflammatory cytokines associated with mental and physical stress. [2 3]

L. Plantarum also plays a key role in regulating inflammation. Daily supplementation was found to reduce production of inflammatory cytokines and reduce oxidative stress in animal models [4]. 

L. Plantarum supports the health and survival of brain cells by suppressing activation of the protein NF-κB, the single most important regulator of inflammation in the body and brain. NF-κB inhibition is linked with brain growth and development. More specifically, inhibition of this protein is associated with improved learning, intelligence, neural plasticity, and memory. synaptic plasticity, BDNF levels are also increased, which enhances cognitive function and the growth of new neurons. [5, 6, 7]

Lactobacillus Brevis

L. Brevis is one of the most well-studied probiotic strains known to influence human health and cognition. The predominant culture in sauerkraut and pickled vegetables, this strain is well known to increase immune function and fight bacterial infection, in addition to its unique effects on the central nervous system. 

L. Brevis provides support against inflammatory compounds associated with impaired memory and cognitive decline. It is one of the essential probiotics for brain health because it increases levels of BDNF, the brain’s all-star growth hormone that controls the health and growth of new neurons. In one study, old rats were given L. Brevis and young rats were given a placebo. The results found that in addition to lowering inflammatory markers TNF, IL1β, and NF-κB L. Brevis significantly increased expression of BDNF to levels greater than the healthy young rats. [8]

This suggests that L. Brevis may restore healthy brain function in elderly populations, possibly to levels greater than healthy young individuals.

L. Brevis has also been shown to have a positive effect on reducing anxiety, depressive symptoms, and restoring a positive mood. [9]

Lactobacillus Helveticus & Bifidobacterium Longum

These are two of the most effective probiotic strains to promote a positive mood, reduce stress, and relieve anxiety and depressive symptoms. 

In one study, consuming a mixture of three Lactobacillus and Bifidobacteria strains for eight weeks significantly reduced depressive symptoms. The probiotic also reduced inflammation in the patients. [10]

A handful of other studies have examined how probiotics affect depressive symptoms in healthy subjects. In healthy people these strains have been found to reduce: 

Symptoms of anxiety [11, 12, 13]
Depressive symptoms [14]
Psychological distress [15]
Academic stress [16]
Researchers also found that taking probiotics reduced participants’ negative thoughts associated with a sad mood. [17]

Open Source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.

Learn About Our Commitment To Transparency

Money Back Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks products, you can return the product within 30 days for a full refund. We also provide actionable tips on our blog and newsletter for you to maximize your performance with our premium products.

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User Reviews

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Rated 5 out of 5

PRO. Biotic.

Pro. As in, the same professional quality you've come to expect from NS. I've been a taking a couple good-quality probiotics (Probiotic 3 and Primal Defense Ultra) for a few years now and completely believe in their essential role in our guts. I've been taking Brain Biotic for 4 days now. I don't know how NS figured out how to combine these specific strains. But what I do know is that you will feel exactly as described. Very focused. Slight feelings of mood improvement. First day I took in the evening, but I wouldn't recommend this as it kept me awake. Last couple of days I've taken in the morning and early afternoon and was fine.

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Citations & References

  1. Liu, Te-Hua, Jiachi Chiou, and Tsung-Yu Tsai. "Effects of Lactobacillus plantarum TWK10-fermented soymilk on deoxycorticosterone acetate-salt-induced hypertension and associated dementia in rats." Nutrients 8.5 (2016): 260.

  2. Liu, Wei-Hsien, et al. "Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice." Behavioural brain research 298 (2016): 202-209.

  3. Liu, Yen-Wenn, et al. "Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice." Brain research 1631 (2016): 1-12.

  4. Toshimitsu, T., et al. "Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice." Journal of dairy science 99.2 (2016): 933-946.

  5. Kassed, Cheryl A., and Miles Herkenham. "NF-κB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety." Behavioural brain research154.2 (2004): 577-584.

  6. Coplan, Jeremy D., et al. "The relationship between intelligence and anxiety: an association with subcortical white matter metabolism." Frontiers in evolutionary neuroscience 3 (2012): 8.

  7. Jeong, J‐J., et al. "Lactobacillus pentosus var. plantarum C29 ameliorates age‐dependent memory impairment in Fischer 344 rats." Letters in applied microbiology 60.4 (2015): 307-314.

  8. Jeong, J-J., et al. "Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice." Beneficial microbes 7.5 (2016): 707-718.

  9. Steenbergen, Laura, et al. "A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood." Brain, behavior, and immunity 48 (2015): 258-264.

  10. Akkasheh, Ghodarz, et al. "Clinical and metabolic response to probiotic administration in patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial." Nutrition 32.3 (2016): 315-320.

  11. Mohammadi, Ali Akbar, et al. "The effects of probiotics on mental health and hypothalamic–pituitary–adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers." Nutritional neuroscience 19.9 (2016): 387-395.

  12. Messaoudi, Michaël, et al. "Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects." British Journal of Nutrition 105.5 (2011): 755-764.

  13. Rao, A. Venket, et al. "A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome." Gut pathogens 1.1 (2009): 6.

  14. Huang, Ruixue, Ke Wang, and Jianan Hu. "Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials." Nutrients 8.8 (2016): 483.

  15. Messaoudi, Michaël, et al. "Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers." Gut microbes 2.4 (2011): 256-261.

  16. Takada, M., et al. "Probiotic Lactobacillus casei strain Shirota relieves stress‐associated symptoms by modulating the gut–brain interaction in human and animal models." Neurogastroenterology & Motility 28.7 (2016): 1027-1036.

Steenbergen, Laura, et al. "A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood." Brain, behavior, and immunity 48 (2015): 258-264.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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