The World’s First Open-Source Supplement Company

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format. 

LEARN ABOUT OUR COMMITMENT TO TRANSPARENCY

01/ GABA For Calm and Relaxation

GABA Brain Food is designed to support the normal, healthy production of GABA, a neurotransmitter essential to mental calmness.

Research suggests that the natural compounds in GABA Brain Food may help reduce temporary feelings of stress, as well as promote relaxation and improve sleep.

  • Promotes feelings of calmness
  • Supports relaxation
  • Supports clear thoughts and calms one’s mind
  • Supports restful, restorative sleep

This natural formula contains the necessary precursors and cofactors for optimal GABA availability.

GABA is a neurotransmitter which acts like a “brake” to keep excitation in check. Too much excitation can lead to irritability, restlessness, and sleep disruption to name a few. GABA’s role as the main inhibitory neurotransmitter helps provide this function in the human body.

GABA is what is known as a self-inhibiting compound. This means, when you take more GABA than your body needs, it blocks its own transport into the brain to maintain constant, normal GABA concentrations. To circumvent this mechanistic limitation, we included the ingredients L-Citrulline, Rosmarinic Acid, and Grape Seed Extract. These natural ingredients work synergistically to both increase GABA’s transport into the brain and work to sustain elevated concentrations of GABA.

Click here to view a diagram of how GABA Brain Food’s ingredients influences natural GABA metabolism.

The main challenge in increasing brain levels of GABA via supplementation is circumventing the molecule’s inherent self-inhibiting characteristic. It is suggested that increasing GABA’s permeability across the blood-brain barrier is an effective target to increase brain levels of GABA. One way to do this is to increase vasodilation by upregulating nitric oxide (NO) production in the body.

L-citrulline is a precursor to the amino acid, L-Arginine, which has a potent effect on stimulating NO production. Additionally, grape seed extract has been shown to increase the production of Endothelial Nitric Oxide Synthase (eNOS), an enzyme used to generate NO from L-Arginine.

Once GABA is made more permeable and able to freely cross the blood-brain barrier with increased NO production, it is naturally broken down by the enzyme GABA-Transaminase (GABA-T). To attenuate the degradation of GABA by GABA-T we incorporated rosmarinic acid into our formulation, which has an inhibitory effect on GABA-T, thus allowing for sustained, elevated levels of GABA in the brain for a longer period of time.

GABA

Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. Gamma-aminobutyric acid (GABA), converted from the principal excitatory neurotransmitter glutamate in the brain, plays a role in regulating neuronal excitability by binding to its receptors, GABA-A and GABA-B, and thereby causing ion channel opening, hyperpolarization and eventually inhibition of neurotransmission. [1]

GABA acts to slow down signals between neurons, making neurons less electrically excitable. [2]

Studies also show that It plays a role in neuronal stem cell differentiation, possibly giving it an important role in adult brain plasticity. [3]

L-Citrulline

Recently, research showed that with an increase in nitric oxide, GABA could more easily cross the blood brain barrier. Nitric oxide also causes GABA release in the hippocampus [4]. In a recent study, GABA supplementation by itself increased brain GABA 33%, but when combined with L-arginine, a stimulator of nitric oxide, brain GABA rose 383.3%. [5]

We chose to use L-Citrulline as the NO-booster in GABA Brain Food because it has been shown to be a more effective NO booster than L-Arginine [6,7,8,9]

Rosmarinic Acid

Rosmarinic acid, present in rosemary, lemon balm, and other herbal agents known for their calming properties, inhibits GABA-transaminase, which slows the breakdown of GABA [10]

Grape Seed Extract

Grape Seed Extract can also upregulate the eNOS enzyme for a further boost to nitric oxide [11]

The National Center for Complementary and Integrative Health (NCCIH) is currently supporting research and studies on other potential abilities of grape seed extract to support healthy cellular function. [12]



02/ Ingredients

GABA(633mg)

As the main inhibitory neurotransmitter in the brain, GABA’s role is to act like a “brake” and balance excessive stimulation. GABA is associated with normal restful sleep, relaxation, tranquil thoughts, and a serenity of mind.

L-Citruline(500mg)

Rosemary Extract(333mg)

Grape Seed Extract(33mg)

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03/ Suggested Use

Take a serving of 1-3 capsules as needed, or as directed by a healthcare practitioner.

U.S.A. manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients.

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100% Happiness Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks supplements, you can keep the full bottle on us and we'll refund your money. Anything after the first bottle, we'll ask that you return for a refund.

average rating 4.9 out of 5
Based on 101 reviews
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100% of reviewers would recommend this product to a friend
Sense of Calm
Rated 4 out of 5
Improved Sleep
Rated 4 out of 5
Deeper Relaxation
Rated 4 out of 5
101 Reviews
Rated 5 out of 5
Review posted

Some of the best sleep I've had in years

with the Magtech and this GABA, I can relax and sleep through the night. I've gone nights without taking the GABA, just the Magtech, and suffered for it.

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Sense of Calm
Rated 5 out of 5
Improved Sleep
Rated 5 out of 5
Deeper Relaxation
Rated 5 out of 5
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Rated 5 out of 5
Review posted

GABA is a must every single night!

I never go to bed without taking my GABA Brain Food! I started about 6 months ago, and the results have been great. I take it to help me relax and fall asleep at night!

What more could you ask for than a natural sleep aid?

I am now subscribed to it, I save 15% and don't have to worry about ever running out!

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Sense of Calm
Rated 5 out of 5
Improved Sleep
Rated 5 out of 5
Deeper Relaxation
Rated 5 out of 5
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Natural Stacks

Glad GABA Brain Food has helped get your sleep schedule on track, Keisha!

Rated 5 out of 5
Review posted

I had a wonderful experience

On the website, I found exactly what I was looking for. This product has helped calm me down and calm my brain down. Especially helpful when trying to get to sleep.

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Sense of Calm
Rated 4 out of 5
Improved Sleep
Rated 3 out of 5
Deeper Relaxation
Rated 4 out of 5
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Rated 5 out of 5
Review posted

Excellent Supplement

I have difficulty sleeping at night and have found that GABA, along with MagTech really helps me get a good nights sleep. These are excellent supplements that have greatly improved my life.

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Sense of Calm
Rated 4 out of 5
Improved Sleep
Rated 5 out of 5
Deeper Relaxation
Rated 4 out of 5
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Rated 5 out of 5
Review posted

Impressive.

This product really surprised me. I have always been a fan of Gaba; not so much with the products that are available, but with the potential of finding a Gaba product that actually works.

Full disclosure. I am an Nutritionist. Most Gaba products do not survive digestion. That's unfortunate because there are a lot of medications that work via Gaba receptors. It only makes sense that we should be able to supplement naturally with Gaba. I believe that Natural Stacks has found a way to make Gaba work. I doubted it a first. And when I first took the supplement, I was waiting for the usual Gaba flush that often comes with Gaba supplements. It did not come. In fact, I didn't feel anything in particular, but here is the thing. I fell asleep easier, and I often have strong food cravings at night. I will wake up in the middle of the night and eat something unhealthy. That didn't happen while I was taking this product. This tells me that Gaba is crossing the BBB. I am pleasantly surprised. I have always wondered if Gaba was bound with Arginine, if that would carry Gaba across the BBB. Natural Stacks uses Citruline, and that seems to work as well if not better. I am really impressed.

There are a couple of Gaba products that work well, primarily phenibut, but they come with some heavy side effects. Natural Stacks does not. I am really impressed. I would definitely recommend.

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Sense of Calm
Rated 3 out of 5
Improved Sleep
Rated 5 out of 5
Deeper Relaxation
Rated 5 out of 5
Was this helpful?

04/ Frequently Asked Questions

What is GABA?

Gamma-aminobutyric acid (GABA) is a neurotransmitter that blocks impulses between nerve cells in the brain. It is thought to be one of the most important chemicals responsible for reducing excess neural stimulation, among other functions.

What is GABA's Function?

What is GABA Brain Food used for?

When should I take GABA Brain Food?

Can GABA help me sleep?

Can I use GABA Brain Food with the rest of the Natural Stacks Brain Food line (Serotonin, Dopamine, Acetylcholine)?

How do my GABA receptors work?