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GABA Brain Food™

For Calmness & Relaxation
For Calmness & Relaxation

GABA Brain Food is designed to support the normal, healthy production of GABA, a neurotransmitter essential to mental calmness.

Research suggests that the natural compounds in GABA Brain Food may help reduce temporary feelings of stress, as well as promote relaxation and improve sleep.

  • Promotes feelings of calmness
  • Supports relaxation
  • Supports clear thoughts and calms one’s mind
  • Supports restful, restorative sleep

This natural formula contains the necessary precursors and cofactors for optimal GABA availability.

Promotes feelings of calmness†

Supports clear thoughts and calms one's mind†

Supports relaxation†

Supports restful, restorative sleep†

Ingredients

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As the main inhibitory neurotransmitter in the brain, GABA’s role is to act like a “brake” and balance excessive stimulation. GABA is associated with normal restful sleep, relaxation, tranquil thoughts, and a serenity of mind.

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An amino acid found in foods like watermelon, dairy, beef and pork. L-citrulline is converted into L-arginine, a known nitric oxide booster, which is theorized to help shuttle GABA into the brain across the blood-brain barrier.

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Found in rosemary, sage, mint and basil, rosmarinic acid is a naturally occurring polyphenol flavonoid. It is also found in lemon balm and is used in aromatherapy to promote feelings of calm and relaxation.

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Similar to L-citrulline, grape seed extract is used to increase nitric oxide production to help GABA pass across the blood-brain barrier and enter the brain.

Gaba

900 mg

As the main inhibitory neurotransmitter in the brain, GABA’s role is to act like a “brake” and balance excessive stimulation. GABA is associated with normal restful sleep, relaxation, tranquil thoughts, and a serenity of mind.

L-Citrulline

500 mg

An amino acid found in foods like watermelon, dairy, beef and pork. L-citrulline is converted into L-arginine, a known nitric oxide booster, which is theorized to help shuttle GABA into the brain across the blood-brain barrier.

Rosemary Extract

333 mg

Found in rosemary, sage, mint and basil, rosmarinic acid is a naturally occurring polyphenol flavonoid. It is also found in lemon balm and is used in aromatherapy to promote feelings of calm and relaxation.

Grape Seed Extract

33 mg

Similar to L-citrulline, grape seed extract is used to increase nitric oxide production to help GABA pass across the blood-brain barrier and enter the brain.

Suggested Use

Take a serving of 1 or 2 capsules as needed, or as directed by a healthcare practitioner.

U.S.A. manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients.

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How It Works

The neurotransmitter GABA acts like a “brake” to keep excitation in check. Too much excitation can lead to irritability, restlessness, and sleep disruption to name a few. GABA’s role as the main inhibitory neurotransmitter helps provide this function in the human body.

GABA is what is known as a self-inhibiting compound. This means, when you take more GABA than your body needs, it blocks its own transport into the brain to maintain constant, normal GABA concentrations. To circumvent this mechanistic limitation, we included the ingredients L-Citrulline, Rosmarinic Acid, and Grape Seed Extract. These natural ingredients work synergistically to both increase GABA’s transport into the brain and work to sustain elevated concentrations of GABA.

Click here to view a diagram of how GABA Brain Food’s ingredients influences natural GABA metabolism.

The main challenge in increasing brain levels of GABA via supplementation is circumventing the molecule’s inherent self-inhibiting characteristic. It is suggested that increasing GABA’s permeability across the blood-brain barrier is an effective target to increase brain levels of GABA. One way to do this is to increase vasodilation by upregulating nitric oxide (NO) production in the body.

L-citrulline is a precursor to the amino acid, L-Arginine, which has a potent effect on stimulating NO production. Additionally, grape seed extract has been shown to increase the production of Endothelial Nitric Oxide Synthase (eNOS), an enzyme used to generate NO from L-Arginine.

Once GABA is made more permeable and able to freely cross the blood-brain barrier with increased NO production, it is naturally broken down by the enzyme GABA-Transaminase (GABA-T). To attenuate the degradation of GABA by GABA-T we incorporated rosmarinic acid into our formulation, which has an inhibitory effect on GABA-T, thus allowing for sustained, elevated levels of GABA in the brain for a longer period of time.

GABA

Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. Gamma-aminobutyric acid (GABA), converted from the principal excitatory neurotransmitter glutamate in the brain, plays a role in regulating neuronal excitability by binding to its receptors, GABA-A and GABA-B, and thereby causing ion channel opening, hyperpolarization and eventually inhibition of neurotransmission. [1]

GABA acts to slow down signals between neurons, making neurons less electrically excitable. [2]

Studies also show that It plays a role in neuronal stem cell differentiation, possibly giving it an important role in adult brain plasticity. [3]

L-Citrulline

Recently, research showed that with an increase in nitric oxide, GABA could more easily cross the blood brain barrier. Nitric oxide also causes GABA release in the hippocampus [4]. In a recent study, GABA supplementation by itself increased brain GABA 33%, but when combined with L-arginine, a stimulator of nitric oxide, brain GABA rose 383.3%. [5]

We chose to use L-Citrulline as the NO-booster in GABA Brain Food because it has been shown to be a more effective NO booster than L-Arginine [6,7,8,9]

Rosmarinic Acid

Rosmarinic acid, present in rosemary, lemon balm, and other herbal agents known for their calming properties, inhibits GABA-transaminase, which slows the breakdown of GABA [10]

Grape Seed Extract

Grape Seed Extract can also upregulate the eNOS enzyme for a further boost to nitric oxide [11]

The National Center for Complementary and Integrative Health (NCCIH) is currently supporting research and studies on other potential abilities of grape seed extract to support healthy cellular function. [12]

The Brain Food™ Series

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Dopamine Brain Food™

FOR MENTAL ALERTNESS

Responsible for motivation, memory, and creativity, dopamine is a key neurotransmitter that also increases alertness and assertiveness.

Learn More
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Serotonin Brain Food™

FOR A POSITIVE MOOD

Designed to support the body's natural production of Serotonin, a neurotransmitter essential to mental well-being.

Learn More

Open Source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.

Learn About Our Commitment To Transparency

Money Back Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks products, you can return the product within 30 days for a full refund. We also provide actionable tips on our blog and newsletter for you to maximize your performance with our premium products.

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Citations & References

1. NIH. U.S. National Library of Medicine. GABA. Compound Summary for CID 5281792 Pub Chem. Open Chemistry Database.

2. Mccormick DA. GABA as an inhibitory neurotransmitter in human cerebral cortex. J Neurophysiol. 1989;62(5):1018-27. PMID 2573696

3. Salazar P, Velasco-velázquez MA, Velasco I. GABA effects during neuronal differentiation of stem cells. Neurochem Res. 2008;33(8):1546-57. PMID 18357524

4. Getting SJ, Segieth J, Ahmad S, Biggs CS, Whitton PS. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Res. 1996;717(1-2):196-9. PMID 8738273

5. Boonstra E, De kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015;6:1520. PMID 26500584

6. Examine: L-Citrulline. Examine.com

7. Kuhn, K. P., et al. Oral citrulline effectively elevates plasma arginine levels for 24 hours in normal volunteers. Circulation 2002; 106: II1–766S.

8. Schwedhelm, E., et al. "Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism," British Journal of Clinical Pharmacology, 65(1):51-9, 2008.

9. Stephen J. Bailey, et. al. L-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol 119: 385–395, 2015.

10. Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT. Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res. 2009;23(8):1075-81.PMID 19165747

11. Feng Z, Wei RB, Hong Q, Cui SY, Chen XM. Grape seed extract enhances eNOS expression and NO production through regulating calcium-mediated AKT phosphorylation in H2O2-treated endothelium. Cell Biol Int. 2010;34(10):1055-61. PMID 20513234

12. US Department of Health and Human Services. National Institute of Health Database. Grape Seed Extract. The National Center for Complementary and Integrative Health (NCCIH)

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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