NEUROFUEL™

$29.95
Rated 4.8 out of 5
501 Reviews

NEUROFUEL™ is the original CILTEP® formula for enhanced focus, deep concentration and improved memory. 

The premium natural ingredients work as fuel for your neurotransmitters, supporting greater signaling between brain cells. 

FEEL THE FUEL within 30 minutes of your first dose. 


Product

The World’s First Open-Source Supplement Company

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format. 

LEARN ABOUT OUR COMMITMENT TO TRANSPARENCY

01/ BUILD A BETTER BRAIN

Do you ever experience "brain fog", where it's impossible to think clearly?

Do you sometimes have trouble focusing and solving complex problems?

Have a big to-do list or goals you want to hit, but no motivation?

This happens to all of us and as we age these things tend to get worse, but the good news is they don't have to!

There's a reason why doctors, firefighters, students, moms and dads around the world are using NEUROFUEL™ to boost their focus, motivation and memory. 

NEUROFUEL™ is a 100% natural formula for better brain performance. 

Whether you're looking to learn a new skill, get a promotion at work, or get back to doing more of the things you love... NEUROFUEL™ can help. 

Users often report:

  • Increased motivation and mental endurance†
  • Improved concentration and alertness†
  • Improved mood and social ease†
  • Enhanced ability to study and learn new information†

All it takes is two capsules on an empty stomach before your work or focus session. Thirty minutes later, you'll feel the fuel go to work.

How It Works

NEUROFUEL™ provides your body the natural ingredients it needs to fuel a process known as It is regarded by many as the key to learning new things and retaining that information. 

That's why we say "FEEL THE FUEL". 

When LTP is enhanced; you'll be alert, intellectually curious, and feel more creative.   

So Powerful That It's Patented.

NEUROFUEL™ is the original CILTEP formula and is protected by US Patent #US9149457B2.

Citations & References

1. Brown JE, Rice-evans CA. Luteolin-rich artichoke extract. Free Radic Res. 1998;29(3):247-55. PMID 9802556 32

2. Yu MC, Chen JH, Lai CY, Han CY, Ko WC. Eur J Pharmacol. 2010;627(1-3):269-75. PMID 19853596

3. Rutten K, Van donkelaar EL, Ferrington L, et al. Neuropsychopharmacology. 2009;34(8):1914-25. PMID 19262466

4. Reneerkens OAH, Rutten K, Steinbusch HWM, Blokland A, Prickaerts J. A promising target for cognition enhancement. Psychopharmacology. 2009;202(1-3):419-443. doi:10.1007/s00213-008-1273-x.

5. Barad M, Bourtchouladze R, Winder DG, Golan H, Kandel E. Proc Natl Acad Sci USA. 1998;95(25):15020-5. PMID 9844008

6. Lelkes Z. Pharmacol Biochem Behav. 1998 Aug;60(4):835-9.

7. Block F1. Neuroreport. 2001 May 25;12(7):1507-11.

8. Chen RW. Neurosci Lett. 2007 May 17;418(2):165-9. Epub 2007 Mar 18.

9. Ammon HP, Müller AB. Forskolin: from an ayurvedic remedy to a modern agent. Planta Med. 1985;51(6):473-7. PMID 17345261

10. Seamon KB, Daly JW. Forskolin: a unique diterpene activator of cyclic AMP-generating systems. J Cyclic Nucleotide Res. 1981;7(4):201-24. PMID 627800

11. Linus Pauling Institute. Micronutrient Information Center: Vitamin B6. http://lpi.oregonstate.edu/mic/vitamins/vitamin-B6

12. Broadley KJ (March 2010). Pharmacol. Ther. 125 (3): 363–375. doi:10.1016/j.pharmthera.2009.11.005. PMID 19948186.

13. Lindemann L, Hoener MC (May 2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends Pharmacol. Sci. 26 (5): 274–281. doi:10.1016/j.tips.2005.03.007. PMID 15860375.

14. Inano A1. Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2. Biopharm Drug Dispos. 2003 Nov;24(8):357-65.

15. Scafidi S, Fiskum G, Lindauer SL, et al. Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain. Journal of neurochemistry. 2010;114(3):820-831. doi:10.1111/j.1471-4159.2010.06807.x.

16. Pettegrew, JW. Molecular Pyschiatry. Nov. 2000, Volume 5, Number 6, Pages 616-632.

17. Cooke SF. Plasticity in the human central nervous system. Brain. 2006 Jul;129(Pt 7):1659-73. Epub 2006 May 3.

18. Bliss TV1. A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993 Jan 7;361(6407):31-9.

19. Bryan J1. Psychological effects of dietary components of tea: caffeine and L-theanine. Nutr Rev. 2008 Feb;66(2):82-90. doi: 10.1111/j.1753-4887.2007.00011.x

20. Curtin BF. Forskolin, an inducer of cAMP, up-regulates acetylcholinesterase expression. Mol Cell Biochem. 2006 Oct;290(1-2):23-32. Epub 2006 Aug 19.

21. Guilarte TR. Neurochem Res. 1989 Jun;14(6):571-8.

22. White HL. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res. 1990 Jun;15(6):597-601.

02/ Ingredients

Artichoke Extract(900 mg)

Artichoke extract contains Luteolin, a natural inhibitor of PDE4 [1,2]. PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Studies have correlated lower levels of the enzyme PDE4 to significant increases in normal mental performance, including increased cognition [3], improved long term memory [4], increased wakefulness [5], and neuroprotection. [6,7,8]

Read More About Artichoke Extract

Forskolin(20 mg)

Forskolin is derived from the plant Coleus forskohlii which has been widely used in traditional Ayurvedic medicine [9]. It has also has been extensively studied due to it’s ability to increase levels of intracellular cAMP molecules [10]. Combined with Luteolin from Artichoke Extract, forskolin is theorized to synergistically increase the duration of cAMP in neurons.

Read More About Forskolin

Acetyl-L-Carnitine(750 mg)

Acetyl-L-Carnitine, or ALCAR, is an acetylated form of the amino acid L-Carnitine that has been shown to cross the blood brain barrier. [14]. Known for its roles in energy metabolism and mitochondrial protection, the addition of ALCAR to the CILTEP formula helps combat feelings of brain fog and fatigue. [15,16]

Read More About Acetyl-L-Carnitine

Vitamin B6(5 mg)

Vitamin B6 is an essential vitamin and an important enzymatic cofactor in normal metabolic and psychological function. [11] CILTEP features the metabolically active form of Vitamin B6 for optimal bioavailability (Pyridoxal-5-Phosphate).

Read More About Vitamin B6

03/ Suggested Use

Take 1-3 capsules in the morning immediately upon waking on an empty stomach, or as directed by a healthcare practitioner. Do not take more than 3 capsules per day.

Some users find that a moderate dose of caffeine in the morning and/or early afternoon extends and optimizes results (We recommend SMART CAFFEINE®).

NEUROFUEL™ can be taken daily, however we advise taking 1-2 days off per week (weekends for example).

U.S.A manufactured in a GMP facility. Natural Stacks proudly uses only the highest quality ingredients.

NEUROFUEL™ is protected by U.S. Patents US10058529B2 and US9149457B2.

Great value icon 1
Great value icon 2
Great value icon 3
Great value icon 4
Great value icon 5

100% Happiness Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks supplements, you can keep the full bottle on us and we'll refund your money. Anything after the first bottle, we'll ask that you return for a refund.

average rating 4.8 out of 5
Based on 501 reviews
  • 5 Stars
    432 Reviews
  • 4 Stars
    61 Reviews
  • 3 Stars
    6 Reviews
  • 2 Stars
    0 Reviews
  • 1 Star
    2 Reviews
501 Reviews
Reviewed by Kimmi K.
NEUROFUEL™
Reviewing
NEUROFUEL™
I recommend this product
Rated 5 out of 5
Review posted

Life changer

I've been having trouble keeping focused for a while now, memory is bad and the level of confusing thoughts clouded me.

I recently started neurofuel and let me tell you!

I didn't expect anything but I had no cloudiness, confusion, scattered thoughts and a number of other concentration issues.

I absolutely Love Neurofuel! I recommended neurofuel to almost everyone I know. I have a better brain already.

Loading...
Was this helpful?
Reviewed by Samuel C.
Verified Buyer
NEUROFUEL™
Reviewing
NEUROFUEL™
I recommend this product
Rated 5 out of 5
Review posted

Take it everyday

Good way to beat back the brain fogginess each day.

Loading...
Was this helpful?
Reviewed by Margaretha B.
Verified Buyer
NEUROFUEL™
Reviewing
NEUROFUEL™
I recommend this product
Rated 5 out of 5
Review posted

Great!!

This, together with DPMN, makes my mornings more energetic and structured. Just love it!

Loading...
Was this helpful?
Reviewed by Richard H.
Verified Buyer
NEUROFUEL™
Reviewing
NEUROFUEL™
I recommend this product
Rated 5 out of 5
Review posted

IT WORKS!!!

The combination of ingredients found in this product provide a synergistic palette that provides a noticeable feeling of clarity and motivation.

Loading...
Was this helpful?
Reviewed by James J.
Verified Buyer
NEUROFUEL™
Reviewing
NEUROFUEL™
I recommend this product
Rated 5 out of 5
Review posted

Awesome experience

This product is a game changer

Loading...
Was this helpful?

04/ Frequently Asked Questions

When should I take NEUROFUEL™​?

We suggest taking NEUROFUEL™ first thing in the morning on days that include demanding cognitive tasks. 

Take it on an empty stomach and 20-30 minutes later, you eat breakfast or - our favorite, have some bulletproof coffee for an extra spark.

How does NEUROFUEL™​ work and what will I feel?

NEUROFUEL™ increases focus and potentiates long-term memory but doesn't rely on neurotransmitter manipulation to elicit this benefit. Because NEUROFUEL™ is not a stimulant and it doesn’t directly impact our neurotransmitters, the “feel” is very subtle.

What you notice most is that time seems to slow, distractions fade away (increased focus), and you have a strong desire to learn/read/work.

The more mentally demanding the task, the more NEUROFUEL™ shines.

Many users prefer to “stack” or combine NEUROFUEL™ with one of our Brain Food products. 

The Brain Food line is designed to give individuals the tools needed to optimize whatever neurotransmitter they may need to moderate on any given day or at any given time.

What is NEUROFUEL™​?

NEUROFUEL™ is a natural nutritional supplement designed for improving and maintaining brain performance. It's theorized to improve learning and memory in the brain by supporting and optimizing levels of intracellular secondary messengers.

Are there any side effects?

There are no known side effects if used as directed. For that reason, thousands of people have chosen all-natural NEUROFUEL™ as their preferred nootropic stack.

What happened to the CILTEP® Nootropic Stack?

CILTEP® (sil-tep) is a nootropic stack or smart drug used to improve mental performance.

It was developed in 2012 by world renowned biohacker Abelard Lindsay, patented and then licensed exclusively to Natural Stacks. 

In 2020, Natural Stacks changed the name of CILTEP® to NEUROFUEL™. 

The same powerful, patented formula remains the same but it's now available at a new lower price. 


What is the science behind NEUROFUEL™?

The formula works by: 

PDE4 Inhibition + Increasing cAMP = Long-Term Potentiation

Developed by Abelard Research, the NEUROFUEL™ Formula is a protected by United States Patent and Trademark Office US9149457B2.

PDE4 INHIBITION

PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. 

Inhibition of PDE4 blocks the breakdown of cAMP, and thereby increases levels of cAMP within brain cells.

This has been shown to lead to increased cognition, improved long term memory, increased wakefulness, and neuroprotection. [3,4,5,6,7,8]

There have been several natural PDE4 inhibitors identified in herbal preparations including luteolin, which is present in artichoke extract. It also inhibits PDE 1 through 5 which have both shown beneficial activity with regards to synaptic plasticity. [1,2]

Artichoke Extract is a safe, effective and natural PDE4 Inhibitor. [1,2] NEUROFUEL™ contains 900 mg of the highest quality Artichoke Extract in each serving.

INCREASING cAMP

The herb Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) has been shown to naturally increase cAMP levels. 

It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. [10]

Neuro Fuel™ features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.

Increasing cAMP and inhibiting its degradation supports Long-Term Potentiation (LTP).

Summary: PDE4 Inhibition + Increasing cAMP → LTP → Supports optimal mental performance

What makes NEUROFUEL ™​ better / different than other smart drugs?

NEUROFUEL™ uses a simple, all-natural formula that works by increasing the number of messenger systems inside of your brain cells. 

This enables neurons to quickly communicate with each other and retain information. It makes you more engaged and efficient at whatever mental task you might be doing.

NEUROFUEL™ enhances your mental capacity without relying on altering neurotransmitter levels. 

It acts inside of the cell to naturally strengthen connections between neurons, promoting improved learning, memory, and cognitive function.