Dopamine Brain Food™ is designed to support the body's natural production of dopamine, a neurotransmitter essential to the central nervous system.
Users typically report:
This natural formula contains precursors and cofactors for optimal dopamine metabolism.
Support normal neurotransmitter metabolism†
Maintain peak cognitive function†
May provide a mild boost in feelings of motivation†
Reduce brain fog and support clear thoughts†
Take a serving of 2 or 3 capsules in the morning, or as directed by a healthcare practitioner. Do not take more than 3 capsules per day.
U.S.A manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients.
Dopamine Brain Food is a nootropic stack made from natural ingredients and formulated to support natural neurotransmitter metabolism for optimal mental performance.
Research shows the neurotransmitter dopamine is associated with confidence, motivation, attention and learning as well as movement and balance.
L-Tyrosine a promising cognitive enhancer
Dutch researchers conducting a meta-analysis on L-tyrosine concluded that this amino acid “is a promising cognitive enhancer” 
Blood levels of L-Tyrosine may be linked to quality of life
A 2004 study found that “normal tyrosine concentrations, compared to increased tyrosine concentrations, may be associated with fatigue and diminished quality of life.”
Specifically, they reported that Physical Functioning, Role Functioning Physical, Bodily Pain, General Health, Vitality, Social Functioning, Role Emotional Functioning, and Mental Health all increased as tyrosine levels increased. 
L-Phenylalanine (and L-Tyrosine) leads to increased alertness and arousal
A peer-reviewed paper published in 2008 concluded that L-Tyrosine and L-Phenylalanine are precursors to the neurotransmitter and that “dietary supplements that contain tyrosine and/or phenylalanine lead to alertness and arousal” 
Vitamin B6 a rate-limiting substrate for dopamine production
Research shows that “the role of vitamin B6 in amino acid metabolism makes it a rate limiting cofactor in the synthesis of neurotransmitters such as dopamine, serotonin, and GABA” 
Vitamin B6 supports healthy immune function and metabolism
A pair of papers from 2012 and 2013 showed that “Vitamin B6 has a direct effect on immune function and gene transcription/expression and plays a role in brain glucose regulation.” [5,6]
Vitamin B6 may support healthy neural cells
A review of cognitive enhancement and prevention studies concluded that Vitamin B6 plays a crucial role in helping the body maintain normal, healthy cognition through the aging process. 
Vitamin B12 supports healthy nerves and neural cell function
A 2006 review of the roles of folate and Vitamin B12 and their impact on the nervous system highlighted the importance of adequate B12 levels for healthy neuronal function. 
The same 2013 study mentioned above shows that Vitamin B12 is crucial for the maintenance of normal, healthy cognitive function and memory recall through one’s lifespan. 
Folate Linked to DNA function and neuronal differentiation
Folate contributes to the normal, healthy functioning of our brains. A 2007 study connected folate to “reactions in brain tissue” including “DNA stability, gene expression/transcription, neuronal differentiation, hippocampal development, and propagation of action potentials”. 
Vitamin C is neuroprotective antioxidant
A 2007 study and a 2009 meta-analysis report that Vitamin C is not only a powerful antioxidant, but that it is also a neuroprotective compound. By reducing oxidative stress and helping to remove metabolic waste, Vitamin C keeps brain cells “cleaner” and supports normal cell functioning. [10,11]
Vitamin C prevents oxidation of vitamins, minerals and amino acids
Vitamin C is the primary antioxidant present in our bloodstream and it exerts its beneficial effects on our cells as well as other vitamins, minerals and amino acids, including 
Selenium levels impact health
Selenium is a mineral involved in many biological processes, including metabolic and immune function. Below normal levels of selenium have been linked to poor health and 2017 review concluded that “the prevention of a deficiency in selenium would be advisable for all individuals.”  (Natural Stacks note: Selenium deficiency in rare in the US)
Selenium linked to healthy metabolism
Scottish researchers examined the impact of selenium on endocrine systems and found that it was closely related to sex hormones and the metabolic hormones thyroid and insulin. They reported that selenium “restores [normal] glycaemic control and modifies the activity of a range of enzymes involved in hepatic glycolysis and gluconeogenesis” and “sperm quality and fertility of the patients improved after selenium supplementation”. 
TMG improves body composition, muscle size, and endurance
Commonly found in beets, spinach and shellfish, TMG or trimethylglycine is also known as Betaine.
Betaine has been used by many athletes and fitness enthusiasts as a natural ergogenic aid. A 2013 study published data supporting TMG’s ability to increase muscle size, work capacity (endurance) and body composition after 6 weeks of supplementation. 
Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.
If for whatever reason you're unsatisfied with your Natural Stacks products, you can return the product within 30 days for a full refund. We also provide actionable tips on our blog and newsletter for you to maximize your performance with our premium products.
1. Jongkees BJ, Hommel B, Colzato LS. People are different: tyrosine’s modulating effect on cognitive control in healthy humans may depend on individual differences related to dopamine function. Frontiers in Psychology. 2014;5:1101. doi:10.3389/fpsyg.2014.01101.
2. Pieter CJ ter Borg, et al. The relation between plasma tyrosine concentration and fatigue. BMC Gastroenterology. 20055:11. DOI: 10.1186/1471-230X-5-11
3. Shaheen E Lakhan, Karen F Vieira. Nutrition Journal. 20087:2 DOI: 10.1186/1475-2891-7-2. Published: 21 January 2008
4. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Nutrients. 2016;8(2):68. doi:10.3390/nu8020068.
5. Dakshinamurti S., Dakshinamurti K. Vitamin b6. In: Zempleni J., Suttie J.W., Gregory J.F. III, Stover P.J., editors. Handbook of Vitamins. 5th ed. CRC Press; Boca Raton, FL, USA: 2013.
6. Anitha M, Abraham PM, Paulose CS. . Striatal dopamine receptors modulate the expression of insulin receptor, IGF-1 and GLUT-3: effect of pyridoxine treatment. European Journal of Pharmacol. 2012 Dec 5; 696(1-3):54-61.
7. Tracy RP. Review Emerging relationships. Int J Obes Relat Metab Disord. 2003 Dec; 27 Suppl 3():S29-34.
8. Reynolds E. Review Vitamin B12, folic acid, and the nervous system. Lancet Neurol. 2006 Nov; 5(11):949-60.
9. Bailey L.B. Folic acid. In: Zempleni J., Rucker R.B., McCormick D.B., Suttie J.W., editors. Handbook of Vitamins. 4th ed. CRC Press; Boca Raton, FL, USA: 2007
10. Santos LF1. Actions of vitamin C. Pharmacol Biochem Behav. 2008 Mar;89(1):1-5. Epub 2007 Oct 23.
11. Harrison FE, May JM. Vitamin C Function in the Brain: Vital Role of the Ascorbate Transporter (SVCT2). Free radical biology & medicine. 2009;46(6):719-730. doi:10.1016/j.freeradbiomed.2008.12.018.
12. Adams AK1 Antioxidant vitamins. Am Fam Physician. 1999 Sep 1;60(3):895-904.
13. Maria G. Boosalis, PhD, MPH, RD, LD. The Role of Selenium. January 6, 2017
14. Geoffrey J Beckett and John R Arthur1. Selenium and endocrine systems. Clinical Biochemistry, University of Edinburgh, The Royal Infirmary of Edinburgh, 51 Little France Crescent, Little France, Edinburgh EH16 4SA, Scotland, UK.
15. Jason M Cholewa, et al. Effects of betaine on body composition, performance, and homocysteine thiolactone. Journal of the International Society of Sports Nutrition. 201310:39. DOI: 10.1186/1550-2783-10-39