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Acetylcholine Brain Food™

For Better Mental Clarity
Rated 4.7 out of 5
82 Ratings
Regular price $39.95 List price



  • For Better Mental Clarity
  • Think Faster and Be More Present
  • Supports Memory and Cognitive Function

Think faster and solve problems with ease.

Use Acetylcholine Brain Food to improve your processing speed and decision making.

Acetylcholine Brain Food can help you concentrate and communicate effectively.

Great for any social situation whether you're at the office, in the classroom, or spending time with loved ones.

Upgrade your processing speed

With increased clarity, you’ll notice the small details and be more present in work and personal experiences.

Acetylcholine is a neurotransmitter also referred to as the learning Molecule. 

Acetylcholine Brain Food includes all natural compounds to support memory and cognitive function.

How It Works

Acetylcholine Brain Food™ is designed to promote the production of acetylcholine, a neurotransmitter essential to mental processing. Research suggests that the natural compounds in Acetylcholine Brain Food™ are associated with memory and cognitive function.

  • Improved attention to detail†
  • Better mental clarity†
  • Faster thinking†
  • Cuts through brain fog†

To make acetylcholine, the brain needs two elements: an acetyl group and a choline molecule.

An acetyl group is a type of simple molecular building block of organic chemistry with a chemical formula of C2H30. The acetyl group is usually present in the brain as Acetyl-CoA. Choline and the acetyl group are grouped together by the enzyme Choline Acetyltransferase (ChAT). 

They are both stored in neurons, released, and then broken down by another enzyme called acetylcholinesterase (AchE). To increase levels of acetylcholine, we use the following approach:

  • Create more acetyl-CoA molecules to provide acetyl groups to ChAT for acetylcholine production.
  • Provide more choline in choline producing (cholinergic) neurons for use by ChAT.
  • Increase or upregulate the activity of ChAT.
  • Decrease the activity of AchE.

Acetylcholine Brain Food™ contains the essential raw materials for the brain to increase production, achieve balance, and maintain prolonged activity of the neurotransmitter acetylcholine -- the Learning Molecule.



There are many different types of acetylcholine precursors, but Alpha GPC has the most evidence supporting its efficacy and superior absorption through the gut wall and passage into the brain. Once in the brain, Alpha-GPC is only one step removed from becoming the bioactive neurotransmitter, acetylcholine.


Vitamin B1, taking the form of Thiamine HCL, is included to increase the production of acetyl-CoA molecules in the brain. These are necessary molecules used to provide acetyl groups to the enzyme Choline Acetyltransferase (ChAT) so it can produce the acetylcholine neurotransmitter.


Pantethine is a high-potency form of Vitamin B-5 that shares the same role as Vitamin B-1 in its utility in generating Acetyl-CoA molecules to be used by ChAT in the production of acetylcholine


White peony extract enhances ChAT activity. By increasing activity of ChAT, we can accelerate the construction of acetylcholine from its chemical constituents


Acetyl-L-Carnitine is an immediate byproduct of metabolism that combines with CoA supplied by Vitamin B5 to produce Acetyl-CoA and Carnitine. At this stage in the process, this newly created Acetyl molecule is then able to join the Acetyl group of the acetylcholine molecule. Research has shown that Acetyl-L-Carnitine may also reduce mental and physical fatigue

Suggested Use

Take a serving of 2-4 capsules to support mental processing speed, or as directed by a healthcare practitioner.

Do not exceed 8 capsules per day.

U.S.A. manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients.

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Open Source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.

Learn About Our Commitment To Transparency

100% Happiness Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks supplements, you can keep the full bottle on us and we'll refund your money. Anything after the first bottle, we'll ask that you return for a refund.

User Reviews

average rating 4.7 out of 5
Based on 82 ratings
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100% of reviewers would recommend this product to a friend
Enhanced Concentration
Rated 4 out of 5
Reduced Brain Fog
Rated 4 out of 5
46 Reviews
Rated 5 out of 5
Review posted


I, with many other people, suffer from mid-day brain fog. I start off strong during the morning and then around noon to 1ish my ability to focus drops. I just pop a few of these, and I'm back in business 30 minutes later. It's amazing.

Enhanced Concentration
Rated 5 out of 5
Reduced Brain Fog
Rated 5 out of 5
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Natural Stacks

Good to hear, Zaim! Glad Acetylcholine Brain Food keeps you focused to be productive!

Rated 5 out of 5
Review posted

This is my go-to supplement for brain power!

I love the clarity I get from taking this everyday. And one thing I have noticed is that if I take it at night my dreams are very vivid which I like sometimes. During the day, when I need to be in a creative groove for hours and am writing or designing, this is my go to supplement. The effect it has on my brain is noticeable. I come up with more ideas, faster and can execute faster. But I don't feel jumpy or like my mind is racing at all. It's hard to explain. I am able to come up with solutions immediately and also think of things for my clients that never have occurred to me before. I am going to be a customer for life. NS has the purest form of Acetylcholine - I have tried to find it and no other products compare to what this does for me.

Enhanced Concentration
Rated 5 out of 5
Reduced Brain Fog
Rated 5 out of 5
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Rated 5 out of 5
Review posted

Great company! Great products!

My blood tests showed I was low on Choline, so I purchased your product and when I go back for the retest hopefully, I will be fine. I use a lot of your products and have had good results.

Enhanced Concentration
Rated 4 out of 5
Reduced Brain Fog
Rated 4 out of 5
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Rated 4 out of 5
Review posted

Works great

I use acetylcholine with the dopamine and ciltep stack. Works great. Usually starts working between 30-45min after taken. Helps with focus and motivation. Helps me stay task oriented.

Enhanced Concentration
Rated 4 out of 5
Reduced Brain Fog
Rated 4 out of 5
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Rated 5 out of 5
Review posted

Surprising results

As a retired pharmacist I understand the biochemical aim of Acetylcholine Brain Food, but I was skeptical that a product taken orally could produce any noticeable results. Boy was I wrong! They kind of snuck up on me but after a few days the brain benefits of this product are undeniable.

Enhanced Concentration
Rated 5 out of 5
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Frequently Asked Questions

What is Acetylcholine?

Acetylcholine is defined as a neurotransmitter that functions as a “neural lubricant”. It enhances or accelerates how nerve synapses communicate with one another. 

It acts as a messenger hormone, carrying signals across nerve synapses. 

Acetylcholine can be both an inhibitory and an excitatory neurotransmitter, able to switch from one function to another depending on the immediate demands of the central nervous system.

What is Acetylcholine's Function?

In the brain, acetylcholine primarily functions as a neurotransmitter and a neuromodulator.

It plays an important role in arousal, attention, memory, and motivation. 

As one of the brain’s most prominent neurotransmitters, acetylcholine acts as a chemical messenger released by nerve cells to send signals to other cells in the body. 

Another function of acetylcholine is to signal muscle movement and contraction.

How is Acetylcholine Different Than Choline?

Acetylcholine is the active neurotransmitter used by the brain to enhance communication across neural synapses. 

Choline is a dietary nutrient and precursor to the neurotransmitter form (acetylcholine). 

Adequate amounts of dietary choline are required for the brain to produce acetylcholine.

What’s the difference between Anticholinergic and Cholinergic?

Parts of the body that use or are affected by acetylcholine are referred to as “cholinergic.” 

Substances or nutrients that interfere or impair acetylcholine activity are called “anticholinergics.” 

Conversely, compounds that enhance acetylcholine activity, balance, or production are collectively called “cholinergics.”

What are the Signs and Symptoms of Choline Deficiency?

Common symptoms of a Choline Deficiency include: low energy, fatigue, memory loss, cognitive decline, learning disabilities, difficulty concentrating, muscular soreness, nerve damage, mood swings. 

Individuals with “fatty liver” disease are often at a higher risk for choline deficiency.

How much Acetylcholine Brain Food should I take and how often?

We recommend taking a serving of 2-3 capsules of Acetylcholine Brain Food™ to support better mental clarity and processing speed. 

Acetylcholine Brain Food™ can safely be taken on a daily basis, but do not exceed two servings per day.

Can I use Acetylcholine with the other Natural Stacks Brain Food Supplements (GABA, Dopamine and Serotonin)?

Yes! Acetylcholine Brain Food™ is a great addition to any Natural Stacks Brain Food™ stack because it acts as a “neural lubricant.” 

This means it works to improve how different regions of the brain talk to each other, making all mental processing faster and more fluid. 

For this reason Acetylcholine Brain Food™ may enhance the effectiveness and duration of GABA, Dopamine, and Serotonin in the brain.

How is Your Acetylcholine Supplement different than other Choline Supplements?

Acetylcholine Brain Food™ was formulated with the science-proven ingredients in the precise amounts known to increase acetylcholine production and keep its action sustained for hours on end. 

The foundation of Acetylcholine Brain Food™ is Alpha GPC, a high-potency version of choline. 

Choline supplements such as Alpha GPC or other choline derivatives are commonly available as standalone ingredients, but none contain the necessary cofactors, vitamins, and amino acids that support the entire metabolic cycle of this vital neurotransmitter. 

Acetylcholine Brain Food™ contains the natural co-factors your brain needs to optimize acetylcholine metabolism naturally.

What Natural Stacks work well with Acetylcholine Brain Food?

Acetylcholine Brain Food™ stacks well with any of the Natural Stacks products, but for best results we recommend taking Acetylcholine with CILTEP and or MycoMIND.

Acetylcholine Brain Food™ helps potentiate the unique benefits of CILTEP and MycoMIND by increasing mental processing speed. CILTEP acts on a specific pathway in the brain (long-term potentiation), MycoMIND functions as a functional nutrient to support all higher-level cognitive function, and Acetylcholine Brain Food™ unites these unique benefits by increasing mental processing speed throughout the brain.

Citations & References

De jesus moreno moreno M. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. Clin Ther. 2003;25(1):178-93. PMID 12637119

Szutowicz A, Bielarczyk H, Jankowska-kulawy A, Pawełczyk T, Ronowska A. Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases. Neurochem Res. 2013;38(8):1523-42. PMID 23677775

Houten SM, Wanders RJ. A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation. J Inherit Metab Dis. 2010;33(5):469-77. 20195903

Arsenio L, Bodria P, Magnati G, Strata A, Trovato R. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clin Ther. 1986;8(5):537-45. PMID 3094958

Malaguarnera M, Gargante MP, Cristaldi E, et al. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. 2008;46(2):181-90. PMID 17658628

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