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Rhodiola Rosea has been shown to have beneficial effects on alleviating cognitive stress and fatigue.
Additionally, it may possess some neuroprotective properties against toxins.
A dose of 400 mg daily (200 mg twice daily) for 4 weeks showed improvements in perceived stress, fatigue, and stress-induced social and work dysfunction .
Additionally, the results of a recent meta-analysis showed that up to 660 mg of rhodiola rosea extract per day reduced cognitive fatigue and improved overall well-being relative to placebo treatment .
Figure 1. Improvements in life-stress symptoms after 4 weeks of rhodiola supplementation
Rhodiola appears to be effective at reducing fatigue when taken acutely or with daily supplementation, and may be effective at attenuating fatigue in chronically fatigued people .
In rodent studies, doses of rhodiola at 50 - 100 mg/kg body weight for 9 days was able to enhance memory in otherwise normal, healthy rats .
Several studies have demonstrated rhodiola’s ability to reduce cognitive fatigue, reduce processing errors during mentally challenging tasks, and increase attention and reaction time [5, 6, 7, 8, 9].
Figure 2. Improvements in anti-fatigue index compared to placebo
Rhodiola has been shown to preserve cognition and there is some evidence suggesting it may improve memory independent of stress and fatigue .
Rhodiola has also been shown to accelerate the rate of nerve healing [11, 12].
Doses of 340 mg or 680 mg of rhodiola per day have been shown to improve mood, sense of well being, and emotional stability .
Preliminary evidence suggests rhodiola may be effective at reducing anxiety. In humans, improvements in generalized anxiety disorder have been observed with supplementation at 340 mg over 10 weeks .
As an adaptogen, rhodiola appears to promote longevity by acting on hormetic pathway DAF-16 to elicit an adaptive stress response [15, 16, 17].
Rhodiola may have application in improving glucose tolerance. One study showed that a dose of rhodiola administered to rats was able to reduce blood glucose by ~50%, comparable to the effects of an equal dose of cinnamon, another known compound to improve postprandial glucose metabolism .