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CILTEP is a natural nootropic that combines artichoke extract and forskolin to naturally induce long-term potentiation. Formulated by its creator Abelard Lindsay, CILTEP is a healthy way to stay focused, alert, and motivated for hours.
Artichoke extract contains Luteolin, a safe natural inhibitor of PDE4. PDE4 inhibitors have been shown to have significant nootropic effects including increased cognition, improved long term memory, increased wakefulness, and neuroprotection.
Forskolin derived from Coleus Forskohlii activates the enzyme adenylyl cyclase which increases intracellular levels of cAMP. The result is an overall improvement of cognitive function, especially memory formation and retention of new information.
ALCAR is an acetylated form of the amino acid L-Carnitine. L-Carnitine is present in many foods but can also be synthesized in the liver. When cAMP is increased in neurons by forskolin, studies have shown that levels of acetylcholinesterase are also increased. We added ALCAR to the stack to help mitigate the effects of increased acetylcholinesterase on short-term memory and energy.
Vitamin B6 is required for the biosynthesis of several neurotransmitters including dopamine, serotonin, and GABA. CILTEP features the metabolically active form of Vitamin B6 (Pyridoxal-5-Phosphate) to ensure optimal cognitive function.
L-Phenylalanine is an essential amino acid found in some foods that the brain uses to make dopamine. This amino acid acts as fuel to support efficient dopamine metabolism for maximum motivation and a positive mood.
"CILTEP is great stuff."
"I'm a huge fan of this stack. What I find personally is that so much of this is dependent on your own individual biochemical signal."
"I've relied on CILTEP as my go-to product to optimize mental performance for the seven week long WSOP."
"It definitely helped me get through the long days and stay focused all the way through. I've noticed a remarkable difference in my ability to spend hours at a table without a break in concentration. This product really works."
"I am seriously impressed with CILTEP"
"CILTEP has earned a place alongside world-class smart drugs like piracetam, gingko, and choline. It works synergistically with them to help you do - and be - more."
CILTEP naturally increases focus and improves memory by inducing Long-Term Potentiation.
Long-Term Potentiation (LTP) is a long lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time. LTP is one of the major cellular mechanisms behind learning and memory. Memories are formed or “encoded” in the brain by creating LTP.
CILTEP achieves LTP by: 1. Inhibiting Phosphodiesterase-4 (PDE4), and 2. Increasing cyclic adenosine monophosphate (cAMP).
PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 Inhibitors have been shown to have significant nootropic effects including increased cognition , improved long term memory , increased wakefulness , and neuroprotection. 
Artichoke Extract is the safest and most effective PDE4 Inhibitor. There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of the highest quality Artichoke Extract in each serving.
An herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.
Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is a significant overall improvement in cognitive function, especially memory formation and retention of new information.
Summary: PDE4 Inhibition + Increasing cAMP → LTP → Learning and Memory
CILTEP makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes. Meanwhile the chemical dynamics of the dopamine system are preserved, avoiding the negative side effects associated with using traditional dopamine stimulation (such as is found in prescription stimulants).
Research has shown that increased intracellular cAMP increases the rate of dopamine and acetylcholine synthesis.[9, 10] L-Phenylalanine, L-Carnitine, and Vitamin B6 are included in the CILTEP formula to maintain optimal neurotransmitter levels.
L-Phenylalanine and L-Carnitine are amino acids found in some foods that the brain uses to make dopamine  and acetylcholine. These natural nutrients synergize perfectly with Artichoke Extract and Forskolin, preventing fatigue and creating long lasting results with a lift in mood.
For an additional boost in drive and focus, moderate doses of natural stimulants stack very well with CILTEP. Certain types of tea and coffee may work but SMART CAFFEINE is ideal for achieving optimal alertness without the nervousness and jitters from regular caffeine sources. Be extremely cautious with stimulants because CILTEP magnifies their effects.
Suggested Use: For optimal mental performance, take a serving of 2-3 capsules immediately upon waking on an empty stomach. Do not take more than 3 capsules per day.
Some users find that a moderate dose of caffeine in the morning and/or early afternoon extends and optimizes results (We recommend SMART CAFFEINE®).
CILTEP® can be taken daily, however we advise taking 1-2 days off per week (weekends for example).
U.S.A manufactured in a GMP facility. Natural Stacks proudly uses only the highest quality ingredients.
CILTEP® is protected under U.S. Patent 9,149,547
Artichoke Extract contains Luteolin which is a natural inhibitor of the enzyme PDE4. This enzyme is present in neurons where it breaks down CREB activating cAMP. CREB activation is important for long-term potentiation, a process vital to learning and memory. Inhibiting PDE4 and thus increasing cAMP levels in neurons has been shown to increase long-term potentiation.
Forskolin is derived from the plant Coleus forskohlii and is used in traditional Indian Ayurvedic medicine. It has the property of increasing levels of cAMP in cells. Combined with Luteolin from Artichoke extract, forskolin synergistically increases the duration and levels of cAMP in neurons.
L-Phenylalanine is an essential amino acid present in many foods. When CREB is activated studies have shown that transcription of the enzyme tyrosine hydroxylase is increased leading to an increased rate of dopamine metabolism . L-Phenylalanine is the natural precursor to dopamine and thus helps supply the necessary amino acid fuel for that metabolism.
ALCAR is an acetylated form of the amino acid L-Carnitine. L-Carnitine is present in many foods but can also be synthesized in the liver. L-Carnitine increases mitochondrial energy production, helps burn fat and combats brain fatigue. We added ALCAR to the CILTEP stack to help mitigate the effects of "brain fatigue" so you can enjoy all day focus and productivity with no crash.
Vitamin B6 is an essential vitamin and an important enzymatic cofactor that helps the body produce essential neurotransmitters including dopamine, serotonin, and GABA. It helps activate DOPA decarboxylase, an enzyme directly downstream from tyrosine hydroxylase in dopamine metabolism and thus helps to maintain optimal dopamine metabolism under conditions of increased Tyrosine Hydroxylase that occur during CREB enhanced LTP.
"The History of the CILTEP Stack"
Do not consume prescription stimulants with CILTEP. Do not use if pregnant, nursing, or under the age of 18. Consult with a healthcare practitioner before taking this or any nutritional supplement if you have or suspect a medical condition, are taking any medications, or other non-Natural Stacks dietary supplements.
CILTEP increases focus and potentiates long-term memory but doesn't rely on neurotransmitter manipulation to elicit this benefit. Because CILTEP is not a stimulant and it doesn’t directly impact our neurotransmitters, the “feel” is very subtle.
What you notice most is that time seems to slow, distractions fade away (increased focus), and you have a strong desire to learn/read/work.
The more mentally demanding the task, the more CILTEP shines.
Many users prefer to “stack” or combine CILTEP with one of our Brain Food products. The Brain Food line is designed to give individuals the tools needed to optimize whatever neurotransmitter they may need to moderate on any given day or at any given time.
CILTEP is a natural nutritional supplement designed for improving and maintaining brain performance. It's theorized to improve learning and memory in the brain by supporting and optimizing levels of intracellular secondary messengers.
There are no known side effects if used as directed. For that reason, thousands of people have chosen all-natural CILTEP as their preferred nootropic stack.
Do I have to cycle CILTEP?
We recommend to cycle off of it once a week but it’s not required.
I’m 16. Can I take CILTEP?
No, CILTEP should only be taken once you’re 18 years old.
Is CILTEP vegan?
Is CILTEP soy-free?
Is the best time to take CILTEP in the morning?
Yes, upon waking is the most desirable time to take CILTEP. Some people do enjoy taking CILTEP later in the day, but we recommend avoiding use in the afternoon / evening to maintain optimal sleep.
May I stack ciltep with piracetam and/or aniracetam?
CILTEP is synergistic with the racetams. Here's a blog post about it: http://optimalperformance.com/ciltep-and-racetams-complementary/. Your stack sounds like a good one. Some people in our forum have written about their experience with the racetams: http://forum.naturalstacks.com/
CILTEP uses a simple, all-natural formula that works by increasing the number of messenger systems inside of your brain cells. This enables neurons to quickly communicate with each other and retain information. It makes you more engaged and efficient at whatever mental task you might be doing.
CILTEP enhances your mental capacity without relying on altering neurotransmitter levels. It acts inside of the cell to naturally strengthen connections between neurons, promoting improved learning, memory, and cognitive function.
Natural Stacks formulas contain premium ingredients which are carefully selected solely on the basis of quality and purity. We actively seek out the most bioavailable forms of each ingredient, and avoid the cheap synthetic forms used by the majority of supplement companies.Learn More
Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. It's a shady and sometimes dangerous practice. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas in an open source format.Learn More
If for whatever reason you're unsatisfied with your Natural Stacks, you can return the product within 30 days for a full refund. We also provide actionable tips on our blog and support in our forum for you to maximize your performance with our premium products.Learn More