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GABA Brain Food™

GABA Brain Food is designed to support the normal, healthy production of GABA, a neurotransmitter essential to mental calmness.

Research suggests that the natural compounds in GABA Brain Food may help reduce temporary feelings of stress, as well as promote relaxation and improve sleep. +

  • Promotes feelings of calmness†
  • Supports relaxation†
  • Supports clear thoughts and calms one’s mind†
  • Supports restful, restorative sleep†

This natural formula contains the necessary precursors and cofactors for optimal GABA availability.

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Relax and Unwind with GABA Brain Food™

GABA Brain Food users report:

  • Increased sense of ease and relaxation†
  • Increased comfort in social situations†
  • Clear thoughts and a calm mind†
  • Reduced feelings of irritability†

The neurotransmitter GABA acts like a “brake” to keep excitation in check. Too much excitation can lead to irritability, restlessness, and sleep disruption to name a few. GABA’s role as the main inhibitory neurotransmitter helps provide this function in the human body.

View GABA Brain Food™ Diagram

GABA is what is known as a self-inhibiting compound. This means, when you take more GABA than your body needs, it blocks its own transport into the brain to maintain constant, normal GABA concentrations. To circumvent this mechanistic limitation, we included the ingredients L-Citrulline, Rosmarinic Acid, and Grape Seed Extract. These natural ingredients work synergistically to both increase GABA’s transport into the brain and work to sustain elevated concentrations of GABA.

The main challenge in increasing brain levels of GABA via supplementation is circumventing the molecule’s inherent self-inhibiting characteristic. It is suggested that increasing GABA’s permeability across the blood-brain barrier is an effective target to increase brain levels of GABA. One way to do this is to increase vasodilation by upregulating nitric oxide (NO) production in the body.

L-citrulline is a precursor to the amino acid, L-Arginine, which has a potent effect on stimulating NO production. Additionally, grape seed extract has been shown to increase the production of Endothelial Nitric Oxide Synthase (eNOS), an enzyme used to generate NO from L-Arginine.  


Once GABA is made more permeable and able to freely cross the blood-brain barrier with increased NO production, it is naturally broken down by the enzyme GABA-Transaminase (GABA-T). To attenuate the degradation of GABA by GABA-T we incorporated rosmarinic acid into our formulation, which has an inhibitory effect on GABA-T, thus allowing for sustained, elevated levels of GABA in the brain for a longer period of time.

Summary:

  • First, our carefully selected ingredients in GABA Brain Food™ work synergistically to boost NO production to increase permeability of GABA across the blood-brain barrier.
  • Next, once GABA enters the brain, catalyzing enzyme GABA-T is inhibited to prevent degradation of GABA and ensure levels are elevated and sustained.

GABA

Gamma-Aminobutyric Acid is a naturally occurring neurotransmitter with central nervous system (CNS) inhibitory activity. Gamma-aminobutyric acid (GABA), converted from the principal excitatory neurotransmitter glutamate in the brain, plays a role in regulating neuronal excitability by binding to its receptors, GABA-A and GABA-B, and thereby causing ion channel opening, hyperpolarization and eventually inhibition of neurotransmission. [1]

GABA acts to slow down signals between neurons, making neurons less electrically excitable. [2]

Studies also show that It plays a role in neuronal stem cell differentiation, possibly giving it an important role in adult brain plasticity. [3]

L-Citrulline

Recently, research showed that with an increase in nitric oxide, GABA could more easily cross the blood brain barrier.  Nitric oxide also causes GABA release in the hippocampus [4]. In a recent study, GABA supplementation by itself increased brain GABA 33%, but when combined with L-arginine, a stimulator of nitric oxide, brain GABA rose 383.3%. [5]

We chose to use L-Citrulline as the NO-booster in GABA Brain Food because it has been shown to be a more effective NO booster than L-Arginine [6,7,8,9]

Rosemarinc Acid

Rosmarinic acid, present in rosemary, lemon balm, and other herbal agents known for their calming properties, inhibits GABA-transaminase, which slows the breakdown of GABA [10]

Grape Seed Extract

Grape Seed Extract can also upregulate the eNOS enzyme for a further boost to nitric oxide [11]

The National Center for Complementary and Integrative Health (NCCIH) is currently supporting research and studies on other potential abilities of grape seed extract to support healthy cellular function. [12]

 

Resources:

  1. NIH. U.S. National Library of Medicine. GABA. Compound Summary for CID 5281792 Pub Chem. Open Chemistry Database.
  2. Mccormick DA. GABA as an inhibitory neurotransmitter in human cerebral cortex. J Neurophysiol. 1989;62(5):1018-27. PMID 2573696
  3. Salazar P, Velasco-velázquez MA, Velasco I. GABA effects during neuronal differentiation of stem cells. Neurochem Res. 2008;33(8):1546-57. PMID 18357524
  4. Getting SJ, Segieth J, Ahmad S, Biggs CS, Whitton PS. Biphasic modulation of GABA release by nitric oxide in the hippocampus of freely moving rats in vivo. Brain Res. 1996;717(1-2):196-9. PMID 8738273
  5. Boonstra E, De kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015;6:1520. PMID 26500584
  6. Examine: L-Citrulline. Examine.com
  7. Kuhn, K. P., et al. Oral citrulline effectively elevates plasma arginine levels for 24 hours in normal volunteers. Circulation 2002; 106: II1–766S.
  8. Schwedhelm, E., et al. "Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism," British Journal of Clinical Pharmacology, 65(1):51-9, 2008.
  9. Stephen J. Bailey, et. al. L-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol 119: 385–395, 2015.
  10. Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT. Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res. 2009;23(8):1075-81.PMID 19165747
  11. Feng Z, Wei RB, Hong Q, Cui SY, Chen XM. Grape seed extract enhances eNOS expression and NO production through regulating calcium-mediated AKT phosphorylation in H2O2-treated endothelium. Cell Biol Int. 2010;34(10):1055-61. PMID 20513234
  12. US Department of Health and Human Services. National Institute of Health Database. Grape Seed Extract. The National Center for Complementary and Integrative Health (NCCIH)

Ingredients:

GABA Brain Food’s functional ingredients are careful selected and formulated to promote optimal mental performance:

GABA

As the main inhibitory neurotransmitter, GABA’s role in the brain is to act like a “brake” and balance excitement. GABA is associated with normal restful sleep, relaxation, healthy movement and state of mind. [1,2]

Rosemarinic Acid

Found in rosemary, sage, mint and basil, rosemarinic acid is a naturally occurring polyphenol flavonoid. It is also found in lemon balm and is used in aromatherapy to promote feelings of calm and relaxation.* [3]

Grape Seed Extract

First developed in the 1970’s grape seed extract contains the antioxidant compound oligomeric proanthocyanidin (OPC) which has shown promise as a dietary supplement to support healthy cellular function.* [4]

L-Citrulline

L-citrulline is an amino acid found in watermelon, dairy, beef, poultry and pork. When taken as a supplement, L-citrulline is converted into L-arginine by the kidneys. + [5]

This innovative formula provides natural ingredients from vitamins, minerals, and amino acids that our bodies use as precursors and cofactors to support normal, healthy function of neurotransmitters.

Resources:

  1. American College for Advancement in Medicine. GABA. Alternative Medicine Review Volume 12, Number 3 2007.
  2. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Frontiers in Psychology. 2015;6:1520. doi:10.3389/fpsyg.2015.01520.
  3. NIH. U.S. National Library of Medicine. Rosemarinic Acid. Compound Summary for CID 5281792 Pub Chem. Open Chemistry Database.
  4. Fine AM. Oligomeric proanthocyanidin complexes: history, structure, and applications. Alternative Medicine Review. 2000;5(2):144-151.
  5. Examine: L-Citrulline. Examine.com

Suggested Use:

Calm Your Mind

SUGGESTED USE: Take a serving of 1 or 2 capsules as needed, or as directed by a healthcare practitioner. Do not take more than 2 capsules per day.

U.S.A manufactured in a cGMP and NSF certified facility. Natural Stacks proudly uses only the highest quality ingredients.

Dedication to quality

Natural Stacks formulas contain premium ingredients which are carefully selected solely on the basis of quality and purity. We actively seek out the most bioavailable forms of each ingredient, and avoid the cheap synthetic forms used by the majority of supplement companies.

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Open source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas in an open source format.

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Money back guarantee

If for whatever reason you're unsatisfied with your Natural Stacks, you can return the product within 30 days for a full refund. We also provide actionable tips on our blog and support in our forum for you to maximize your performance with our premium products.

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