CILTEP Nootropic Stack - 60 Capsules
per month
CILTEP Nootropic Stack - 60 Capsules


CILTEP Nootropic Stack - 60 Capsules has a rating of 4.1 stars based on 142 reviews.
Free Smart Caffeine Sample with every Ciltep Purchase
CILTEP is a natural nootropic that combines artichoke extract and forskolin to naturally induce
long-term potentiation. Formulated by its creator Abelard Lindsay, CILTEP is a healthy way to stay
focused, alert, and motivated for hours.
Maximum Motivation and
Mental Endurance
Increased Ability To Study and Retain Information
Boost Concentration and
Long-Term Memory
Improved Mood and
Social Ability

CILTEP is used every day by thousands of people around the world,
including CEOs, Wall Street Executives, college students, scientists and creatives.

Users typically experience results for 8-14 hours. One bottle contains 60 capsules.
Premium Antichoke Extract
Artichoke extract contains Luteolin, a safe natural inhibitor of PDE4. PDE4 inhibitors have been shown to have significant nootropic effects including increased cognition, improved long term memory, increased wakefulness, and neuroprotection.
Forskolin derived from Coleus Forskohlii activates the enzyme adenylyl cyclase which increases intracellular levels of cAMP. The result is an overall improvement of cognitive function, especially memory formation and retention of new information.
ALCAR is an acetylated form of the amino acid L-Carnitine. L-Carnitine is present in many foods but can also be synthesized in the liver. When cAMP is increased in neurons by forskolin, studies have shown that levels of acetylcholinesterase are also increased. We added ALCAR to the stack to help mitigate the effects of increased acetylcholinesterase on short-term memory and energy.
Vitamin B-6
Vitamin B6 is required for the biosynthesis of several neurotransmitters including dopamine, serotonin, and GABA. CILTEP features the metabolically active form of Vitamin B6 (Pyridoxal-5-Phosphate) to ensure optimal cognitive function.
L-Phenylalanine is an essential amino acid found in some foods that the brain uses to make dopamine. This amino acid acts as fuel to support efficient dopamine metabolism for maximum motivation and a positive mood.

CILTEP works by naturally inducing Long-Term Potentiation

Long-Term Potentiation (LTP) is a long lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time.[1]  LTP is one of the major cellular mechanisms behind learning and memory.[1][2] Memories are formed or “encoded” in the brain by creating LTP.

CILTEP achieves LTP by: 1. Inhibiting Phosphodiesterase-4 (PDE4), and 2. Increasing cyclic adenosine monophosphate (cAMP).


PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 Inhibitors have been shown to have significant nootropic effects including increased cognition [3], improved long term memory [4], increased wakefulness [5], and neuroprotection.[6] [7]

Artichoke Extract is the safest and most effective PDE4 Inhibitor. There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of the highest quality Artichoke Extract in each serving.


An herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.

Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is a significant overall improvement in cognitive function, especially memory formation and retention of new information.

Summary: PDE4 Inhibition + Increasing cAMP → LTP → Learning and Memory


CILTEP makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes.[8] Meanwhile the chemical dynamics of the dopamine system are preserved, avoiding the negative side effects associated with using traditional dopamine stimulation (such as is found in prescription stimulants).

Research has shown that increased intracellular cAMP increases the rate of dopamine and acetylcholine synthesis.[9, 10] L-Phenylalanine, L-Carnitine, and Vitamin B6 are included in the CILTEP formula to maintain optimal neurotransmitter levels.

L-Phenylalanine and L-Carnitine are amino acids found in some foods that the brain uses to make dopamine [11] and acetylcholine.[12] These natural nutrients synergize perfectly with Artichoke Extract and Forskolin, preventing fatigue and creating long lasting results with a lift in mood.


For an additional boost in drive and focus, moderate doses of natural stimulants stack very well with CILTEP. Certain types of tea and coffee may work but SMART CAFFEINE is ideal for achieving optimal alertness without the nervousness and jitters from regular caffeine sources. Be extremely cautious with stimulants because CILTEP magnifies their effects.



Motivation. Concentration. Memory.

Suggested Use: For optimal mental performance, take a serving of 2-3 capsules immediately upon waking on an empty stomach. Do not take more than 3 capsules per day.

Some users find that a moderate dose of caffeine in the morning and/or early afternoon extends and optimizes results (We recommend SMART CAFFEINE).

CILTEP can be taken daily, however we advise taking 1-2 days off per week (weekends for example).

U.S.A manufactured in a GMP facility. Natural Stacks proudly uses only the highest quality ingredients.

Artichoke Extract

Artichoke Extract contains Luteolin which is a natural inhibitor of the enzyme PDE4. This enzyme is present in neurons where it breaks down CREB activating cAMP. CREB activation is important for long-term potentiation, a process vital to learning and memory. Inhibiting PDE4 and thus increasing cAMP levels in neurons has been shown to increase long-term potentiation.


Forskolin is derived from the plant Coleus forskohlii and is used in traditional Indian Ayurvedic medicine. It has the property of increasing levels of cAMP in cells. Combined with Luteolin from Artichoke extract, forskolin synergistically increases the duration and levels of cAMP in neurons.


L-Phenylalanine is an essential amino acid present in many foods. When CREB is activated studies have shown that transcription of the enzyme tyrosine hydroxylase is increased leading to an increased rate of dopamine metabolism . L-Phenylalanine is the natural precursor to dopamine and thus helps supply the necessary amino acid fuel for that metabolism.

Acetyl-L-Carnitine (ALCAR)

ALCAR is an acetylated form of the amino acid L-Carnitine. L-Carnitine is present in many foods but can also be synthesized in the liver. When cAMP is increased in neurons by forskolin, studies have shown that levels of acetylcholinesterase are also increased. We added ALCAR to the stack to help mitigate the effects of increased acetylcholinesterase on short-term memory and energy.

Vitamin B6

Vitamin B6 is an essential vitamin and an important enzymatic cofactor that helps the body produce essential neurotransmitters including dopamine, serotonin, and GABA. It helps activate DOPA decarboxylase, an enzyme directly downstream from tyrosine hydroxylase in dopamine metabolism and thus helps to maintain optimal dopamine metabolism under conditions of increased Tyrosine Hydroxylase that occur during CREB enhanced LTP.

"The History of the CILTEP Stack"


  • Abelard Lindsay begins brain hacking.


  • Abelard joined back when it was called Immortality Institute.


  • Abelard started researching PDE4 Inhibitor/Forskolin connection.
  • Abelard started taking Luteolin in the form of Artichoke Extract with Forskolin.  Results were so good that he had trouble believing that he wasn’t going to have some sort of negative reaction or tolerance.


  • After several months of trials with only positive results Abelard reveals the Artichoke and Forskolin stack on the forum. (LINK)
  • Abelard named the stack “CILTEP”.
  • Interest in CILTEP begins to skyrocket on
  • The first stack FAQ/Summary was created.
  • Abelard began experiments with Quercetin and other PDE4 inhibitors, which were later abandoned.
  • L-Phenylalanine was added to the stack.
  • Tim Ferriss mentions Artichoke Extract and Forskolin stack at Google Tech Talk. (LINK)


  • thread reaches 100,000 views. (LINK)
  • Tim Ferriss mentions Artichoke Extract and Forskolin stack on Joe Rogan show #320. (LINK)
  • Abelard recommended that Vitamin B6 be added to the stack. (LINK)
    • Tim Ferriss mentions Artichoke Extract and Forskolin stacks on “The random show #21” and credits Abelard Lindsay as the inventor. (LINK)
    • Abelard announced that his research on CILTEP is open source.
    • Natural Stacks and Abelard start collaboration on producing a CILTEP product.
    • Acetyl-L-Carnitine was added to the stack to combat ACHE upregulation. (LINK1, LINK2)
    • thread reaches 350,000 views.
    • Abelard joins the Natural Stacks team as Director of Research & Development. (LINK)
    • Natural Stacks releases the worlds first and only CILTEP product. (LINK)


    Do not consume nicotine or prescription stimulants with CILTEP. Do not use if pregnant, nursing, or under the age of 18. Consult with a healthcare practitioner before taking this or any nutritional supplement if you have or suspect a medical condition, are taking any medications, or other non-Natural Stacks dietary supplements.

    What is CILTEP?

    CILTEP is a natural nutritional supplement designed for improving and maintaining brain performance. It's theorized to improve learning and memory in the brain by supporting and optimizing levels of intracellular secondary messengers.

    Are there any side effects?

    There are no known side effects if used as directed. For that reason, thousands of people have chosen all-natural CILTEP as their preferred nootropic stack.  

    Is CILTEP FDA approved?

    Dietary supplements are not reviewed and approved by the Food and Drug Administration (FDA).  CILTEP is an over the counter dietary supplement and does not require FDA approval, but CILTEP is quality-tested, manufactured, and packaged in FDA registered facilities.

    Is CILTEP regulated by the FDA?

    As a dietary supplement CILTEP's package labeling, ingredients, and manufacturing quality are regulated by the FDA pursuant to the Federal Food, Drug and Cosmetic Act.

    How is the product shipped from

    We proudly offer FREE regular ground shipping for all order from the United States. We offer 3 shipping options:

    • United States – FREE  - Regular Ground Shipping (3-5 days)
    • United States – $20 - Expedited Air Shipping (2-3 days)
    • International – $9.95 - Regular Shipping (6-15 days)

    Shipments are made Monday through Friday. Weekend delivery is not available. All "Regular" shipments are sent via USPS First Class Mail. International orders to some countries may take longer than 15 days and may be subject to duties and/or taxes.

    Is there a money back guarantee?

    Yes! All orders purchased through are backed by our 30-day 100% money back guarantee from the date of purchase. If in the unlikely event you are not completely satisfied with your purchase, you can return your product for a refund. Shipping & handling charges and additional opened products after the first bottle are not refundable.

    Natural Stacks formulas contain premium ingredients which are carefully selected solely on the basis of quality and purity. We actively seek out the most bioavailable forms of each ingredient, and avoid the cheap synthetic forms used by the majority of supplement companies.
    Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. It's a shady and sometimes dangerous practice. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas in an open source format.
    If for whatever reason you're unsatisfied with your Natural Stacks, you can return the product within 30 days for a full refund. We also provide actionable tips on our blog and support in our forum for you to maximize your performance with our premium products.