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"Ever since I discovered the Ciltep and Smart Caffeine pre-workout stack I’ve been hooked! No side effects at all, no dependency or withdrawl and the highest quality pre-workout on the market. I’ve recently added BioCreatine to my pre-workout stack, I’m so excited to see the results."
"CILTEP is great stuff.
I'm a huge fan of this stack. What I find personally is that so much of this is dependent on your own individual biochemical signal."
"I am seriously impressed with CILTEP.
CILTEP has earned a place alongside world-class smart drugs like piracetam, gingko, and choline. It works synergistically with them to you do - and be - more."
"I have been taking Natural Stacks products for a few weeks now and already notice a huge difference. I feel more awake with more energy and also more alert on a continual consistent basis every day at practice and meetings...I have never felt better than I do now!"
"Ive relied on CILTEP as my go-to product to optimize mental performance for the seven week long WSOP."
"It definitely helped me get through the long days and stay focused all the way through. I've noticed a remarkable difference in my ability to spend hours at a table without a break in concentration. This product really works."
"CILTEP has been by far the most impressive nootropic I've ever tried, period."
"If you've never tried nootropics before, or have, and noticed meager results, then CILTEP might be worth a try. Unlike most racetams, the effects are rapid and.."
"I am thrilled to be part of the team at Natural Stacks. The products are leading the way in terms of performance enhancement both physically and mentally. I have become more in-tune with the need to continue to nourish and enhance my cognitive functions, so Natural Stacks makes all the sense in the world to me."
""Ever since I discovered the Ciltep and Smart Caffeine pre-workout stack I’ve been hooked! No side effects at all, no dependency or withdrawl and the highest quality pre-workout on the market. I’ve recently added BioCreatine to my pre-workout stack, I’m so excited to see the results."
"CILTEP is great stuff."
"I'm a huge fan of this stack. What I find personally is that so much of this is dependent on your own individual biochemical signal."
CILTEP works by naturally inducing Long-Term Potentiation.
Long-Term Potentiation (LTP) is a long lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time. LTP is one of the major cellular mechanisms behind learning and memory. Memories are formed or “encoded” in the brain by creating LTP.
CILTEP achieves LTP by: 1. Inhibiting Phosphodiesterase-4 (PDE4), and 2. Increasing cyclic adenosine monophosphate (cAMP).
PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 Inhibitors have been shown to have significant nootropic effects including increased cognition , improved long term memory , increased wakefulness , and neuroprotection. 
Artichoke Extract is the safest and most effective PDE4 Inhibitor. There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of the highest quality Artichoke Extract in each serving.
An herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.
Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is a significant overall improvement in cognitive function, especially memory formation and retention of new information.
Summary: PDE4 Inhibition + Increasing cAMP → LTP → Learning and Memory
CILTEP makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes. Meanwhile the chemical dynamics of the dopamine system are preserved, avoiding the negative side effects associated with using traditional dopamine stimulation (such as is found in prescription stimulants).
Research has shown that increased intracellular cAMP increases the rate of dopamine and acetylcholine synthesis.[9, 10] L-Phenylalanine, L-Carnitine, and Vitamin B6 are included in the CILTEP formula to maintain optimal neurotransmitter levels.
L-Phenylalanine and L-Carnitine are amino acids found in some foods that the brain uses to make dopamine  and acetylcholine. These natural nutrients synergize perfectly with Artichoke Extract and Forskolin, preventing fatigue and creating long lasting results with a lift in mood.
For an additional boost in drive and focus, moderate doses of natural stimulants stack very well with CILTEP. Certain types of tea and coffee may work but SMART CAFFEINE is ideal for achieving optimal alertness without the nervousness and jitters from regular caffeine sources. Be extremely cautious with stimulants because CILTEP magnifies their effects.
Suggested Use: For optimal mental performance, take a serving of 2-3 capsules immediately upon waking on an empty stomach. Do not take more than 3 capsules per day.
Some users find that a moderate dose of caffeine in the morning and/or early afternoon extends and optimizes results (We recommend SMART CAFFEINE®).
CILTEP® can be taken daily, however we advise taking 1-2 days off per week (weekends for example).
U.S.A manufactured in a GMP facility. Natural Stacks proudly uses only the highest quality ingredients.
Artichoke Extract contains Luteolin which is a natural inhibitor of the enzyme PDE4. This enzyme is present in neurons where it breaks down CREB activating cAMP. CREB activation is important for long-term potentiation, a process vital to learning and memory. Inhibiting PDE4 and thus increasing cAMP levels in neurons has been shown to increase long-term potentiation.
Forskolin is derived from the plant Coleus forskohlii and is used in traditional Indian Ayurvedic medicine. It has the property of increasing levels of cAMP in cells. Combined with Luteolin from Artichoke extract, forskolin synergistically increases the duration and levels of cAMP in neurons.
L-Phenylalanine is an essential amino acid present in many foods. When CREB is activated studies have shown that transcription of the enzyme tyrosine hydroxylase is increased leading to an increased rate of dopamine metabolism . L-Phenylalanine is the natural precursor to dopamine and thus helps supply the necessary amino acid fuel for that metabolism.
ALCAR is an acetylated form of the amino acid L-Carnitine. L-Carnitine is present in many foods but can also be synthesized in the liver. When cAMP is increased in neurons by forskolin, studies have shown that levels of acetylcholinesterase are also increased. We added ALCAR to the stack to help mitigate the effects of increased acetylcholinesterase on short-term memory and energy.
Vitamin B6 is an essential vitamin and an important enzymatic cofactor that helps the body produce essential neurotransmitters including dopamine, serotonin, and GABA. It helps activate DOPA decarboxylase, an enzyme directly downstream from tyrosine hydroxylase in dopamine metabolism and thus helps to maintain optimal dopamine metabolism under conditions of increased Tyrosine Hydroxylase that occur during CREB enhanced LTP.
"The History of the CILTEP Stack"
Do not consume nicotine or prescription stimulants with CILTEP. Do not use if pregnant, nursing, or under the age of 18. Consult with a healthcare practitioner before taking this or any nutritional supplement if you have or suspect a medical condition, are taking any medications, or other non-Natural Stacks dietary supplements.
CILTEP is a natural nutritional supplement designed for improving and maintaining brain performance. It's theorized to improve learning and memory in the brain by supporting and optimizing levels of intracellular secondary messengers.
There are no known side effects if used as directed. For that reason, thousands of people have chosen all-natural CILTEP as their preferred nootropic stack.
Dietary supplements are not reviewed and approved by the Food and Drug Administration (FDA). CILTEP is an over the counter dietary supplement and does not require FDA approval, but CILTEP is quality-tested, manufactured, and packaged in FDA registered facilities.
As a dietary supplement CILTEP's package labeling, ingredients, and manufacturing quality are regulated by the FDA pursuant to the Federal Food, Drug and Cosmetic Act.
We proudly offer FREE regular ground shipping for all order from the United States. We offer 3 shipping options:
Shipments are made Monday through Friday. Weekend delivery is not available. All "Regular" shipments are sent via USPS First Class Mail. International orders to some countries may take longer than 15 days and may be subject to duties and/or taxes.
Yes! All orders purchased through NaturalStacks.com are backed by our 30-day 100% money back guarantee from the date of purchase. If in the unlikely event you are not completely satisfied with your purchase, you can return your product for a refund. Shipping & handling charges and additional opened products after the first bottle are not refundable.