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Gut Health Stack

Probiotics For Your Brain, PLUS Prebiotics For Digestive Health & Metabolism
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  • Probiotics For Your Brain
  • Prebiotics For Digestive Health & Metabolism
  • Optimize the Gut-Brain Connection

Happy Gut & Happy Life

Optimize the gut-brain connection to benefit your mood, memory, and brain health.

With BrainBiotic and a healthy gut you can improve your cognitive function at any stage of your life.

BrainBiotic is designed to support the gut-brain axis.

Prebiotic+ features a blend of natural prebiotics that encourage growth of healthy bacteria. 

Boosted metabolism, optimal digestion, and deeper sleep are all benefits of taking Prebiotic+.

Friendly Bacteria For Your Gut & Probiotics for your Brain

Lower stress, defeat brain fog, and support your memory with BrainBiotic. Maintain the proper PH level in your gut resulting in decreased bloating and increased metabolism.

Good bacteria are key to regulating blood sugar and fighting off sickness.

Our stomach is often referred to as our second brain.

A healthy connection between your gut and your mind is proven to unlock benefits for your mood, memory, brain health, and cognitive function.

How It Works

Brainbiotic™ is premium blend of probiotic strains designed to support the gut - brain axis. 

Research suggests that the probiotic strains in Brainbiotic™ are associated with increased brain-derived neurotrophic factor (BDNF), memory enhancement, and relief of stress-related symptoms.†

  • Gut-Brain Axis Optimizer
  • Defeat Brain Fog
  • Memory Support
  • Stress Relief

The microbiome is essential to health, immune function, and plays a major role in the communication between the gut and the brain. Over the past few years scientists have begun to understand the importance of the microbiome in the context of brain function. Studies show that the gut-brain axis (gut-brain connection) is deeply linked with numerous aspects of cognition including mood, memory, and brain health. By targeting the gut-brain axis with key probiotic strains we’re able to activate a positive immune response in the brain while improving cognitive function at any stage of life.

Probiotics are the healthy microbes our gut needs to function at its best. Within the gut is a vast and diverse “rainforest” of hundreds of different bacterial organisms. Over the past 5 years over 4,000 studies have investigated the link between the health of the gut microbiome and the health of the human brain. We’ve long known the gut’s role in immune function and digestion, but only in recent years have scientists discovered the powerful connection between gut and mind. Of all the studies looking at the gut-brain axis, researchers have identified 4 key strains that have been proven to unlock benefits related to mood, memory, brain health, and higher level cognitive functions. 

With the probiotics found in Brainbiotic™ you can support your brain while supporting your gut at the sametime.

Lactobacillus Plantarum

L. Plantarum is a beneficial and versatile probiotic strain, able to survive stomach acid with ease, allowing it to reach the colon fully active and intact. Here, the probiotic strain is effective at maintaining, restoring, and balancing the gut microbiota.

Studies have shown that L. Plantarum can support long-term memory by increasing levels of the all-star brain growth hormone, brain-derived neurotrophic factor (BDNF).  The culture has also been shown to improve cognitive abilities in rats by lowering pressure and exerting neuroprotective properties in brain cells. [1]

Regular consumption of L. Plantarum may also reduce anxiety. The strain was found to increase levels of dopamine and serotonin while reducing anxiety symptoms, depressive symptoms, and inflammatory cytokines associated with mental and physical stress. [2 3]

L. Plantarum also plays a key role in regulating inflammation. Daily supplementation was found to reduce production of inflammatory cytokines and reduce oxidative stress in animal models [4]. 

L. Plantarum supports the health and survival of brain cells by suppressing activation of the protein NF-κB, the single most important regulator of inflammation in the body and brain. NF-κB inhibition is linked with brain growth and development. More specifically, inhibition of this protein is associated with improved learning, intelligence, neural plasticity, and memory. synaptic plasticity, BDNF levels are also increased, which enhances cognitive function and the growth of new neurons. [5, 6, 7]

Lactobacillus Brevis

L. Brevis is one of the most well-studied probiotic strains known to influence human health and cognition. The predominant culture in sauerkraut and pickled vegetables, this strain is well known to increase immune function and fight bacterial infection, in addition to its unique effects on the central nervous system. 

L. Brevis provides support against inflammatory compounds associated with impaired memory and cognitive decline. It is one of the essential probiotics for brain health because it increases levels of BDNF, the brain’s all-star growth hormone that controls the health and growth of new neurons. In one study, old rats were given L. Brevis and young rats were given a placebo. The results found that in addition to lowering inflammatory markers TNF, IL1β, and NF-κB L. Brevis significantly increased expression of BDNF to levels greater than the healthy young rats. [8]

This suggests that L. Brevis may restore healthy brain function in elderly populations, possibly to levels greater than healthy young individuals.

L. Brevis has also been shown to have a positive effect on reducing anxiety, depressive symptoms, and restoring a positive mood. [9]

Lactobacillus Helveticus & Bifidobacterium Longum

These are two of the most effective probiotic strains to promote a positive mood, reduce stress, and relieve anxiety and depressive symptoms. 

In one study, consuming a mixture of three Lactobacillus and Bifidobacteria strains for eight weeks significantly reduced depressive symptoms. The probiotic also reduced inflammation in the patients. [10]

A handful of other studies have examined how probiotics affect depressive symptoms in healthy subjects. In healthy people these strains have been found to reduce: 

Symptoms of anxiety [11, 12, 13] Depressive symptoms [14] Psychological distress [15] Academic stress [16] Researchers also found that taking probiotics reduced participants’ negative thoughts associated with a sad mood. [17]

features a blend of natural prebiotics to encourage the growth of beneficial bacteria (such as bifidobacteria and lactobacilli). Research suggests that the compounds in Prebiotic+™ can improve gut and overall health. 

The benefits may include optimal digestion, increased metabolism, and deeper sleep.†

How it Works:

Pro-biotics are the “good bacteria” that comprise our gut microbiome and are part of a healthy, fully-functioning digestive system.

Pre-biotics are a class of indigestible starchy plant fibers that promote gut and overall health by encouraging the growth of “friendly” gut flora (such as bifidobacteria and lactobacilli). Resistant starches “resist” digestion and pass through the digestive system largely intact until they reach the large intestine (the colon).

There, our gut bacteria ferment these prebiotics into short chain fatty acids acetate, propionate, and butyrate. These fatty acids help maintain proper pH in the gut, regulate blood sugar, increase satiety, and discourage the growth of “unfriendly” bacteria.

Unmodified Potato Starch & Green Banana Flour

In 2004, Nutrition & Metabolism found that “replacement of 5.4% of total dietary carbohydrate with RS significantly increased post­prandial lipid oxidation and therefore could decrease fat accumulation in the long-­term.” [1]

The American Journal for Clinical Nutrition found in 2005 that “dietary supplementation with resistant starch has the potential to improve insulin sensitivity.” [2]

The American Physiological Society found that “interactions between RS and the colonic microflora appear to be of benefit to the host in the short and long term. ” [3]

The results of a study from 2015 published in The International Journal of Environmental Research and Public Health showed that a single dose of resistant starch from green banana flour not only improved the glucose response after a meal in both lean and overweight individuals, but it improved glucose and insulin levels for 48 hours [4].


In 2009, the Journal of Physiology and Biochemistry found that Inulin FOS contributes to a wide range of health improvements: “FOS have important beneficial physiological effects such as low carcinogenicity, a prebiotic effect, improved mineral absorption and decreased levels of serum cholesterol.” [5]

The Canadian Journal of Microbiology published a paper finding that “fructooligosaccharides represent a prebiotic fiber that supports the growth of a wide range of probiotic cultures and as such has a potential to improve the successfulness of probiotic treatments” [6]

Inulin­FOS can also improve the pH balance of the digestive system, by creating greater levels of the short chain fatty acid butyrate, according to a paper in the Journal of Human Nutrition and Dietetics: “Butyrate concentrations were higher in patients receiving the FOS/fibre ­enriched formula compared to standard formula” [7]


A 2013 study in Autophagy found that trehalose enhances autophagy in motoneurons, thereby slowing the progression of amyotrophic lateral sclerosis, also known as Lou Gehrig’s Disease: “At the mechanistic level, trehalose treatment led to a significant upregulation in the expression of key autophagy-­related genes at the mRNA level… Consistent with these changes, trehalose administration enhanced the nuclear translocation of FOXO1, an important transcription factor involved in the activation of autophagy in neurons.” [8]

Current Drug Targets published a paper in 2014 that trehalose has unique neuroprotective properties: “Mounting experimental evidence suggests that trehalose may prevent neurodegenerative disorders by stabilizing proteins and promoting autophagy.” [9]

In a 2005 paper published in Neurobiology of Disease reported that “trehalose, a simple disaccharide, has been shown to be effective in preventing the deactivation of numerous proteins and in protecting cells against stress.” [10]

Ceylon Cinnamon

Cinnamon has been researched extensively over the years and is well known for its anti­inflammatory properties. In 2012, The Journal of Traditional Complementary Medicine published research that found that “after chemical profiling of cinnamon's components, their biological activities including antimicrobial, antiviral, antioxidant, antitumor, anti-hypertension, antilipemic, antidiabetes, gastroprotective and immunomodulatory were reported by many investigators.” [11]

The European Journal of Clinical Investigation noted in 2006 that in people suffering from type 2 diabetes, “subjects with a higher initial plasma glucose level may benefit more from cinnamon intake… The cinnamon extract seems to have a moderate effect in reducing fasting plasma glucose concentrations in diabetic patients with poor glycemic control.” [12]

According to research published in The Proceedings of Nutrition Society’s 2008 publication, “Subjects with the metabolic syndrome who consume an aqueous extract of cinnamon have been shown to have improved fasting blood glucose, systolic blood pressure, percentage body fat and increased lean body mass.” [13



Lacto P. offers robust probiotic support against inflammatory compounds associated with impaired memory and cognitive decline. The strain has also been shown to increase BDNF to support the health and growth of new brain cells.


This unique strain is known to increase levels of the all-star brain growth hormone, brain-derived neurotrophic factor (BDNF). Higher levels of BDNF are associated with increased intelligence, positive mood, productivity, memory, as well as a decreased risk of various neurodegenerative mental states.


Daily use of this strain has been shown to support gut bacteria associated with positive mood states. The cultures accomplish this by relieving stress-related gut inflammation and increasing production of calming neurotransmitters in the gut to support a positive mood and relieve stress.


Daily use of this strain has been shown to support gut bacteria associated with positive mood states. The cultures accomplish this by relieving stress-related gut inflammation and increasing production of calming neurotransmitters in the gut to support a positive mood and relieve stress.

Suggested Use

PreBiotic+™ Resistant Starch Complex
Mix with 4-6 oz of cold water or into your favorite smoothie. Start by taking 1 tablespoon per day for 1 week then increase to 2 tablespoons per day, preferably in the evening.

BrainBiotic™ Brain Health Probiotics
Take 1-2 capsules per day, or as directed by a healthcare practitioner.

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Open Source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.

Learn About Our Commitment To Transparency

100% Happiness Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks supplements, you can keep the full bottle on us and we'll refund your money. Anything after the first bottle, we'll ask that you return for a refund.

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Great stack!

The stack was great. More mental clarity than i can recall in many years. Thank you!

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Frequently Asked Questions

What makes BrainBiotic better than Probiotic Supplements?

BrainBiotic improves upon commercial probiotic supplements in three important ways:

Strain Specificity

Many conventional probiotic supplements on the market today follow a “blanket” approach to their formulations. This means many different strains (up to 30 in some cases) are included in a single formula. To the consumer, the concept of more = better is appealing, but the reality is that not all probiotic strains are created equal. Many strains are included as fillers, with little to no studied benefits at all. Other strains may even be problematic to those sensitive to the side effects of histamines. BrainBiotic was formulated on results of over 5,000 scientific studies, which collectively suggest that selecting the specific probiotic strains with proven health benefits is a better approach than mixing and matching many different strains with no specific purpose.

BrainBiotic includes only the very best probiotic strains known to support the gut-brain axis to achieve mood, memory, and cognitive health benefits.


BrainBiotic™ is fully shelf-stable and requires no refrigeration. Probiotics are living, fragile organisms susceptible to damage from temperature and moisture, and unless they are properly manufactured and stored, they can easily lose their potency and effectiveness. To ensure maximum potency and stability, BrainBiotic™ uses a freeze-drying process which eliminates moisture and keeps cultures in-tact and shelf stable. Freeze drying temporarily arrests the growth of the bacteria and eliminates moisture. Once ingested, the moisture from your gut reactivates their growth and activity in the gut microbiome. We also use an oxygen resistant sealed glass bottle which minimizes temperature, humidity, and light.

No filler ingredients.

Many probiotic supplements on the market contain up to 90% filler ingredients, with just 10% of the formula coming from the active ingredients that provide all the benefits. Fillers can include the individual strains themselves (strains that are cheaper and or provide weaker health benefits) or filler ingredients such as maltodextrin, rice flour, magnesium stearate, or otherwise unnecessary “bulk” to fill the supplement capsules.

BrainBiotic™ contains only 4 probiotic strains that are most linked to improvements in mood, memory, brain health, and gut function. Our capsules are small and easy to swallow because there are no unnecessary filler ingredients or additives, making BrainBiotic™ one of the purest, most potent probiotics available today.

How does BrainBiotic target the Gut-Brain Axis?

The probiotic strains in BrainBiotic target the Gut-Brain Axis in a few ways.

  • Increased brain-derived neurotrophic factor (BDNF)
  • Support neurotransmitter production
  • Inflammation support
  • Healthy gut function

Collectively these mechanisms contribute to benefits related to mood, stress-relief, memory, brain health, and gut function.

What is the Gut-Brain Axis? Why is it important?

The Gut-Brain Axis is the biochemical signaling that takes places between the gastrointestinal tract (your gut) and the central nervous system (your brain). 

This link is important because the function of one organ has been shown to directly influence function of the other. Disruption or imbalance of your gut microbiome can lead to mental imbalances such as poor mood, memory issues, stress or anxiety. Your gut flora play a large role in the gut-brain axis, and probiotics like those included in BrainBiotic™ have been shown to support this connection, and in turn, lend support to mood, anxiety-relief, memory, and cognitive health.

How many CFU's does BrainBiotic have?

BrainBiotic™ contains approximately 6 billion CFUs.

Why doesn't BrainBiotic have to be refrigerated like other Probiotics?

BrainBiotic™ is formulated using a special freeze-drying technology. 

This process eliminates moisture and significantly improves potency and shelf-life. Freeze drying the probiotic cultures temporarily arrests their growth, while keeping them fully intact and stable. Once the BrainBiotic™ capsules are ingested and make it to your gut, the natural moisture from the gut reactivates the dormant cultures, enabling them to grow and support your microbiome with maximum effectiveness.

When should I take my Probiotic Supplement?

Unless otherwise specified, Probiotic supplements can be taken at any time of day, with or without food.

Are there any Probiotic Side Effects?

Side effects from general probiotic use may include gas, diarrhea, bloating, or gastrointestinal discomfort, but these adverse effects typically subside after a few days of probiotic use once your gut adjusts to the new bacterial strains.

What are the main benefits of taking a Probiotic?

Probiotic offer a wide range of benefits including (but not limited to):

  • Improved digestion
  • Memory support
  • Immune support
  • Inflammation support
  • Stress-relief
  • Balanced mood
  • Relief from depressive symptoms
  • Reduced food intolerances or allergic responses

Who is BrainBiotic for?

BrainBiotic™ is for normal, health-conscious individuals living a modern lifestyle who want an easy, effective way to improve gut health and support brain health at the same time.

What other Natural Stacks work well with BrainBiotic?

BrainBiotic™ is compatible with all Natural Stacks product and can safely be taken alongside our entire catalog of supplements.

For superior gut support, we recommend taking Prebiotic+ Resistant Starch. For advanced gut support, it’s best to take a PRE-biotic and a PRO-biotic.  

Probiotics are the living cultures in your gut microbiome that help make enzymes, neurotransmitters, and hormones that send signals throughout the body. 

Prebiotics such as fiber or resistant starch are not living bacterial cultures, but function as “food” or “fertilizer” for gut bacteria. By taking both prebiotics and probiotics, you’re able to introduce healthy new bacteria and give them the nutrition they need to grow and thrive in the gut microbiome.

PRE-biotics are fuel for your PRO-biotics.

Citations & References

  1. Liu, Te-Hua, Jiachi Chiou, and Tsung-Yu Tsai. "Effects of Lactobacillus plantarum TWK10-fermented soymilk on deoxycorticosterone acetate-salt-induced hypertension and associated dementia in rats." Nutrients 8.5 (2016): 260.

  2. Liu, Wei-Hsien, et al. "Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice." Behavioural brain research 298 (2016): 202-209.

  3. Liu, Yen-Wenn, et al. "Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice." Brain research 1631 (2016): 1-12.

  4. Toshimitsu, T., et al. "Identification of a Lactobacillus plantarum strain that ameliorates chronic inflammation and metabolic disorders in obese and type 2 diabetic mice." Journal of dairy science 99.2 (2016): 933-946.

  5. Kassed, Cheryl A., and Miles Herkenham. "NF-κB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety." Behavioural brain research154.2 (2004): 577-584.

  6. Coplan, Jeremy D., et al. "The relationship between intelligence and anxiety: an association with subcortical white matter metabolism." Frontiers in evolutionary neuroscience 3 (2012): 8.

  7. Jeong, J‐J., et al. "Lactobacillus pentosus var. plantarum C29 ameliorates age‐dependent memory impairment in Fischer 344 rats." Letters in applied microbiology 60.4 (2015): 307-314.

  8. Jeong, J-J., et al. "Anti-inflammaging effects of Lactobacillus brevis OW38 in aged mice." Beneficial microbes 7.5 (2016): 707-718.

  9. Steenbergen, Laura, et al. "A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood." Brain, behavior, and immunity 48 (2015): 258-264.

  10. Akkasheh, Ghodarz, et al. "Clinical and metabolic response to probiotic administration in patients with major depressive disorder: a randomized, double-blind, placebo-controlled trial." Nutrition 32.3 (2016): 315-320.

  11. Mohammadi, Ali Akbar, et al. "The effects of probiotics on mental health and hypothalamic–pituitary–adrenal axis: A randomized, double-blind, placebo-controlled trial in petrochemical workers." Nutritional neuroscience 19.9 (2016): 387-395.

  12. Messaoudi, Michaël, et al. "Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects." British Journal of Nutrition 105.5 (2011): 755-764.

  13. Rao, A. Venket, et al. "A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome." Gut pathogens 1.1 (2009): 6.

  14. Huang, Ruixue, Ke Wang, and Jianan Hu. "Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials." Nutrients 8.8 (2016): 483.

  15. Messaoudi, Michaël, et al. "Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers." Gut microbes 2.4 (2011): 256-261.

  16. Takada, M., et al. "Probiotic Lactobacillus casei strain Shirota relieves stress‐associated symptoms by modulating the gut–brain interaction in human and animal models." Neurogastroenterology & Motility 28.7 (2016): 1027-1036.

Steenbergen, Laura, et al. "A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood." Brain, behavior, and immunity 48 (2015): 258-264.

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