PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, and thereby increases levels of cAMP within brain cells.
This has been shown to lead to increased cognition, improved long term memory, increased wakefulness, and neuroprotection. [3,4,5,6,7,8]
There have been several natural PDE4 inhibitors identified in herbal preparations including luteolin, which is present in artichoke extract. It also inhibits PDE 1 through 5 which have both shown beneficial activity with regards to synaptic plasticity. [1,2]
Artichoke Extract is a safe, effective and natural PDE4 Inhibitor. [1,2] CILTEP contains 900 mg of the highest quality Artichoke Extract in each serving.
For an additional boost in feelings of drive and focus, moderate doses of coffee or tea stack very well with CILTEP. Certain types of tea and coffee may work but SMART CAFFEINE is ideal for achieving optimal alertness without the jittery feeling from regular caffeine sources.  Be extremely cautious with stimulants because CILTEP may magnify their effects.
The herb Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) has been shown to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. 
CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.
CILTEP is the first ever product to combine these two, has been awarded a US patent, and is currently involved in multiple placebo-controlled, double-blind University studies.
Increasing cAMP and inhibiting its degradation supports Long-Term Potentiation (LTP).
Summary: PDE4 Inhibition + Increasing cAMP → LTP → Supports optimal mental performance