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The World’s First Open-Source Supplement Company

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format. 


01/ How It Works

Brainbiotic™ is premium blend of probiotic strains designed to support the gut - brain axis. 

Research suggests that the probiotic strains in Brainbiotic™ are associated with increased brain-derived neurotrophic factor (BDNF), memory enhancement, and relief of stress-related symptoms.†

  • Gut-Brain Axis Optimizer
  • Defeat Brain Fog
  • Memory Support
  • Stress Relief

The microbiome is essential to health, immune function, and plays a major role in the communication between the gut and the brain. Over the past few years scientists have begun to understand the importance of the microbiome in the context of brain function. Studies show that the gut-brain axis (gut-brain connection) is deeply linked with numerous aspects of cognition including mood, memory, and brain health. By targeting the gut-brain axis with key probiotic strains we’re able to activate a positive immune response in the brain while improving cognitive function at any stage of life.

Probiotics are the healthy microbes our gut needs to function at its best. Within the gut is a vast and diverse “rainforest” of hundreds of different bacterial organisms. Over the past 5 years over 4,000 studies have investigated the link between the health of the gut microbiome and the health of the human brain. We’ve long known the gut’s role in immune function and digestion, but only in recent years have scientists discovered the powerful connection between gut and mind. Of all the studies looking at the gut-brain axis, researchers have identified 4 key strains that have been proven to unlock benefits related to mood, memory, brain health, and higher level cognitive functions. 

With the probiotics found in Brainbiotic™ you can support your brain while supporting your gut at the sametime.

Lactobacillus Plantarum

L. Plantarum is a beneficial and versatile probiotic strain, able to survive stomach acid with ease, allowing it to reach the colon fully active and intact. Here, the probiotic strain is effective at maintaining, restoring, and balancing the gut microbiota.

Studies have shown that L. Plantarum can support long-term memory by increasing levels of the all-star brain growth hormone, brain-derived neurotrophic factor (BDNF).  The culture has also been shown to improve cognitive abilities in rats by lowering pressure and exerting neuroprotective properties in brain cells. [1]

Regular consumption of L. Plantarum may also reduce anxiety. The strain was found to increase levels of dopamine and serotonin while reducing anxiety symptoms, depressive symptoms, and inflammatory cytokines associated with mental and physical stress. [2 3]

L. Plantarum also plays a key role in regulating inflammation. Daily supplementation was found to reduce production of inflammatory cytokines and reduce oxidative stress in animal models [4]. 

L. Plantarum supports the health and survival of brain cells by suppressing activation of the protein NF-κB, the single most important regulator of inflammation in the body and brain. NF-κB inhibition is linked with brain growth and development. More specifically, inhibition of this protein is associated with improved learning, intelligence, neural plasticity, and memory. synaptic plasticity, BDNF levels are also increased, which enhances cognitive function and the growth of new neurons. [5, 6, 7]

Lactobacillus Brevis

L. Brevis is one of the most well-studied probiotic strains known to influence human health and cognition. The predominant culture in sauerkraut and pickled vegetables, this strain is well known to increase immune function and fight bacterial infection, in addition to its unique effects on the central nervous system. 

L. Brevis provides support against inflammatory compounds associated with impaired memory and cognitive decline. It is one of the essential probiotics for brain health because it increases levels of BDNF, the brain’s all-star growth hormone that controls the health and growth of new neurons. In one study, old rats were given L. Brevis and young rats were given a placebo. The results found that in addition to lowering inflammatory markers TNF, IL1β, and NF-κB L. Brevis significantly increased expression of BDNF to levels greater than the healthy young rats. [8]

This suggests that L. Brevis may restore healthy brain function in elderly populations, possibly to levels greater than healthy young individuals.

L. Brevis has also been shown to have a positive effect on reducing anxiety, depressive symptoms, and restoring a positive mood. [9]

Lactobacillus Helveticus & Bifidobacterium Longum

These are two of the most effective probiotic strains to promote a positive mood, reduce stress, and relieve anxiety and depressive symptoms. 

In one study, consuming a mixture of three Lactobacillus and Bifidobacteria strains for eight weeks significantly reduced depressive symptoms. The probiotic also reduced inflammation in the patients. [10]

A handful of other studies have examined how probiotics affect depressive symptoms in healthy subjects. In healthy people these strains have been found to reduce: 

Symptoms of anxiety [11, 12, 13] Depressive symptoms [14] Psychological distress [15] Academic stress [16] Researchers also found that taking probiotics reduced participants’ negative thoughts associated with a sad mood. [17]

Citations & References

02/ Ingredients

Lactobacillus Plantarum(2 billion CFU)

Lacto P. offers robust probiotic support against inflammatory compounds associated with impaired memory and cognitive decline. The strain has also been shown to increase BDNF to support the health and growth of new brain cells.

Lactobacillus Helveticus(2.7 billion CFU)

Lactobacillus Brevis(1 billion CFU)

Bifidobacterium Longum(0.3 billion CFU)


03/ Suggested Use

Take 1-2 capsules per day, or as directed by a healthcare practitioner. 

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100% Happiness Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks supplements, you can keep the full bottle on us and we'll refund your money. Anything after the first bottle, we'll ask that you return for a refund.

average rating 5.0 out of 5
Based on 76 reviews
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76 Reviews
Reviewed by Martha F.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted


I've been using this product for a few weeks and can feel a difference already. I'm more focused and motivated to begin the day!

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Reviewed by Richard H.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted


I can say without hesitation that my cognitive abilities have improved significantly since I began using this product.

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Reviewed by Jennifer L.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Love this probiotic

High quality, using to reset my gut after taking antibiotics. Seems like it's having a positive effect.

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Reviewed by Douglas N.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Its a good product

I like talking brainbotics because it really helps me with my brain function

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Reviewed by Jan W.
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Pretty amazing

I had been feeling a little 'brain slow'. Not foggy, just the brain processes seemed slower than normal. Since taking BrainBiotic for 2 weeks that has completely gone. Love the product.

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04/ Frequently Asked Questions

What makes BrainBiotic better than Probiotic Supplements?

BrainBiotic improves upon commercial probiotic supplements in three important ways:

Strain Specificity

Many conventional probiotic supplements on the market today follow a “blanket” approach to their formulations. This means many different strains (up to 30 in some cases) are included in a single formula. To the consumer, the concept of more = better is appealing, but the reality is that not all probiotic strains are created equal. Many strains are included as fillers, with little to no studied benefits at all. Other strains may even be problematic to those sensitive to the side effects of histamines. BrainBiotic was formulated on results of over 5,000 scientific studies, which collectively suggest that selecting the specific probiotic strains with proven health benefits is a better approach than mixing and matching many different strains with no specific purpose.

BrainBiotic includes only the very best probiotic strains known to support the gut-brain axis to achieve mood, memory, and cognitive health benefits.


BrainBiotic™ is fully shelf-stable and requires no refrigeration. Probiotics are living, fragile organisms susceptible to damage from temperature and moisture, and unless they are properly manufactured and stored, they can easily lose their potency and effectiveness. To ensure maximum potency and stability, BrainBiotic™ uses a freeze-drying process which eliminates moisture and keeps cultures in-tact and shelf stable. Freeze drying temporarily arrests the growth of the bacteria and eliminates moisture. Once ingested, the moisture from your gut reactivates their growth and activity in the gut microbiome. We also use an oxygen resistant sealed glass bottle which minimizes temperature, humidity, and light.

No filler ingredients.

Many probiotic supplements on the market contain up to 90% filler ingredients, with just 10% of the formula coming from the active ingredients that provide all the benefits. Fillers can include the individual strains themselves (strains that are cheaper and or provide weaker health benefits) or filler ingredients such as maltodextrin, rice flour, magnesium stearate, or otherwise unnecessary “bulk” to fill the supplement capsules.

BrainBiotic™ contains only 4 probiotic strains that are most linked to improvements in mood, memory, brain health, and gut function. Our capsules are small and easy to swallow because there are no unnecessary filler ingredients or additives, making BrainBiotic™ one of the purest, most potent probiotics available today.

How does BrainBiotic target the Gut-Brain Axis?

What is the Gut-Brain Axis? Why is it important?

Why doesn't BrainBiotic have to be refrigerated like other Probiotics?

Are there any Probiotic Side Effects?

What are the main benefits of taking a Probiotic?

Who is BrainBiotic for?

What other Natural Stacks work well with BrainBiotic?