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Ciltep Overview

CILTEP naturally increases focus and improves memory by inducing Long-Term Potentiation.

Long-Term Potentiation (LTP) is a long lasting enhancement in signal transmission between two neurons that results from stimulating them both at the same time.[1]  LTP is one of the major cellular mechanisms behind learning and memory.[1][2] Memories are formed or “encoded” in the brain by creating LTP.

CILTEP achieves LTP by: 1. Inhibiting Phosphodiesterase-4 (PDE4), and 2. Increasing cyclic adenosine monophosphate (cAMP).


PDE4 is an enzyme that breaks down cAMP molecules, messenger systems that relay signals in the brain. Inhibition of PDE4 blocks the breakdown of cAMP, thereby increasing levels of cAMP within brain cells. PDE4 Inhibitors have been shown to have significant nootropic effects including increased cognition [3], improved long term memory [4], increased wakefulness [5], and neuroprotection.[6] [7]

Artichoke Extract is the safest and most effective PDE4 Inhibitor. There are other herbal supplements that can also perform PDE4 Inhibition but they have all been found to have significant side effects. CILTEP has 900 mg of the highest quality Artichoke Extract in each serving.


An herbal supplement named Forskolin (active compound extracted from the root of the Coleus Forskohlii plant) is the only known supplement to naturally increase cAMP levels. It activates the enzyme adenylyl cyclase which then increases intracellular levels of cAMP. CILTEP features premium Coleus Forskohlii standardized for 20% Forskolin. There are 4 mg of Forskolin in each serving of CILTEP.

Increasing cAMP and inhibiting its degradation (through PDE4 Inhibition) induces Long-Term Potentiation (LTP). The result is a significant overall improvement in cognitive function, especially memory formation and retention of new information.

Summary: PDE4 Inhibition + Increasing cAMP → LTP → Learning and Memory


CILTEP makes normal dopamine metabolism more effective at triggering the motivation, learning, and memory processes.[8] Meanwhile the chemical dynamics of the dopamine system are preserved, avoiding the negative side effects associated with using traditional dopamine stimulation (such as is found in prescription stimulants).

Research has shown that increased intracellular cAMP increases the rate of dopamine and acetylcholine synthesis.[9, 10] L-Phenylalanine, L-Carnitine, and Vitamin B6 are included in the CILTEP formula to maintain optimal neurotransmitter levels.

L-Phenylalanine and L-Carnitine are amino acids found in some foods that the brain uses to make dopamine [11] and acetylcholine.[12] These natural nutrients synergize perfectly with Artichoke Extract and Forskolin, preventing fatigue and creating long lasting results with a lift in mood.


For an additional boost in drive and focus, moderate doses of natural stimulants stack very well with CILTEP. Certain types of tea and coffee may work but SMART CAFFEINE is ideal for achieving optimal alertness without the nervousness and jitters from regular caffeine sources. Be extremely cautious with stimulants because CILTEP magnifies their effects.



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