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Serotonin Brain Food™

For A Positive Mood
Rated 4.7 out of 5
218 Ratings
Regular price $39.95 List price



  • Natural Mood and Stress Support
  • Feel Your Best, and Get More Done
  • Boost Your Mood Anytime, Anywhere

Natural mood and stress support, for everything in life.

Use Serotonin Brain Food to boost your mood, anytime and anywhere.

Life doesn’t have to feel so crazy and stressful all of the time. Serotonin Brain Food is your go-to for natural mood support. 

Use it to relax and be more productive.

Feel like your best self, and get more done.

With a positive mood, you’re exciting to be around and much more productive.

Serotonin is a key neurotransmitter linked to mood, happiness, and positive outlook.

Serotonin Brain Food includes all of the natural ingredients your body needs.

How Serotonin Brain Food Works

Serotonin Brain Food™ is designed to support the body's natural production of serotonin, a neurotransmitter essential to mental well-being.

  • Supports a positive mood†
  • Maintains healthy appetite & digestion†
  • Promotes calmness & sense of well-being†
  • Relieves stress & frustration†

This natural formula contains the precursors and cofactors required for healthy serotonin metabolism.

By providing your body the nutrients it needs to metabolize these neurotransmitters, it is able to achieve optimal levels naturally. 

This method of naturally finding optimal levels also removes the chance of habituation or down-regulation, so you can safely take our Brain Foods to achieve and maintain optimal levels of Serotonin for long-term use



Used in traditional Chinese medicine for hundreds of years, this well-studied adaptogenic herb supports recovery and may reduce feelings of stress and anxiety. It has also been linked to improved mood, providing an uplifting boost in performance and energy.* [5,6]

Read More About Rhodiola Rosea

L-Tryptophan is an essential amino acid that is one of the required nutrients for natural serotonin synthesis. The most common dietary sources of tryptophan include nuts and seeds, meats and dairy, fish and legumes.* [7]

Read More About L-Tryptophan

Vitamin B-3 (Niacinamide) is an essential vitamin that is also a

necessary cofactor for the proper metabolism of fat, carbohydrate,
protein, and alcohol. It’s also closely involved in cell signaling and
DNA repair. It’s used most extensively in the brain, gut and skin, which
have a high cellular turnover rate. Our Vitamin B-3 source is a
niacinamide, which has been carefully selected to reduce incidences of
flushing - many other Vitamin B-3 sources are niacin, which can cause
uncomfortable skin flushing.*

Read More About Vitamin B3

Magnesium Glycinate supports normal attention, memory, and stress reduction.* [8]

Read More About Magnesium Glycinate

Zinc glycinate is a critical factor in maintaining a healthy immune system, supporting optimal cell division and replication.* [9]

This innovative formula provides natural ingredients from vitamins, minerals, and amino acids that our bodies use as precursors and cofactors to support normal, healthy function of neurotransmitters.

Read More About Zinc Glycinate

Suggested Use

Please consult with a medical doctor before combining Serotonin Brain Food™ with other medications.

Take a serving of 2-3 capsules to support a positive mood, during situations of stress or irritability, or as directed by a healthcare practitioner. 

Do not exceed 2 servings per day.

U.S.A manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients.

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Open Source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.

Learn About Our Commitment To Transparency

The Brain Food™ Series

Dopamine Brain Food™

Dopamine Brain Food™


Responsible for motivation, memory, and creativity, dopamine is a key neurotransmitter that also increases alertness and assertiveness.

Learn More
GABA Brain Food™

GABA Brain Food™


Responsible for generating sensations of calm and relaxation. GABA acts like a “brake” to keep mental excitation in check.

Learn More

100% Happiness Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks supplements, you can keep the full bottle on us and we'll refund your money. Anything after the first bottle, we'll ask that you return for a refund.

User Reviews

average rating 4.7 out of 5
Based on 218 ratings
  • 5 Stars
    171 Reviews
  • 4 Stars
    37 Reviews
  • 3 Stars
    4 Reviews
  • 2 Stars
    3 Reviews
  • 1 Star
    3 Reviews
100% of reviewers would recommend this product to a friend
Improved Mood
Rated 4 out of 5
Enhanced Sense Of Wellbeing
Rated 4 out of 5
Reduced Stress
Rated 4 out of 5
138 Reviews
Rated 5 out of 5
Review posted

It got my threw my brother's illness and death

My brother was diagnosed with brain cancer 2 years ago. I already had some of this product that I used occasionally for PMS, etc. It became my life saver for doctor's visits, bad news, sad & stressful situations. I noticed a definite difference on the days I took it and we went to the doctor vs days I forgot to take it. Everything still hurt, but I didn't collapse or go hysterical as the bad news just got worse. It helped me cope with an impossible situation. Dealing with certain family members even now that he's been gone a year is still difficult, so I always bring my Serotonin when I have to interact with them.

If you fly off the handle in seemingly benign situations, can't cope with some people or stressful situations, or just wish that your emotions were less volatile, give this a chance. No side effects, you just weather the storm easier, without crazy ups and downs. Things which would make you want to lash out at someone verbally now still annoy you, but you can hold your tongue. They roll off your back like a duck in water.

I do not say this lightly. I don't know how I could have coped with the last 2 years without this product, and I use it regularly now. Because when does life not get to you unexpectedly sometimes?

Improved Mood
Rated 5 out of 5
Enhanced Sense Of Wellbeing
Rated 5 out of 5
Reduced Stress
Rated 5 out of 5
Was this helpful?
Rated 5 out of 5
Review posted

Game Changer

I’ve been dealing with severe depression on and off since I was 18. After 5+ years on SSRI’s, I tapered off to a huge onslaught of new symptoms: chronic dibiltating anxiety and irritability, anger, lack of motivation (which resulted in a little bit of weight gain) and the worst: chronic telogen effluvium (hair loss) for almost 3 years accompanied with trychodynia (scalp pain).

After having some very dark thoughts for the last few months, I decided to make a change. I incorporated Serotonin Brain Food and felt a change IMMEDIATELY. I can not stress that enough. I felt a difference so significant the next day, that I got my butt to the gym and have cut gluten out of my diet. I am also taking a few other vitamins to support my mental well being but I am amazed at how much this product has helped me. I feel joy. I feel calm. I can sleep and don’t feel exhausted all day! I’ve been taking 2 capsules every evening before I go to bed for the last week and am a new person. I’m not sure if it would be better to take them in the morning but so far this is working for me.

Give it a whirl y’all!

Improved Mood
Rated 5 out of 5
Enhanced Sense Of Wellbeing
Rated 5 out of 5
Reduced Stress
Rated 5 out of 5
Was this helpful?
Rated 4 out of 5
Review posted


This was really god but a bit expensive to be honest.

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Rated 5 out of 5
Review posted

It really works!

I’ve been taking the seratonin brain food for about a month now and I’ve noticed a huge difference in my overall levels of anxiety. I’ve been thinking back and realizing a specific scenario or thing that would cause me a great deal of anxiety and might even trigger a panic attack has been uneventful. I’ve had lessened anxiety overall since I’ve been taking the seratonin brain food and it’s very noticeable. Even in high stress situations it’s as if I’m more able to slow down and think through before my anxiety takes over. I’m very very happy with this product and feel like it’s completely life changing! Highly recommend!!

Improved Mood
Rated 4 out of 5
Enhanced Sense Of Wellbeing
Rated 5 out of 5
Reduced Stress
Rated 5 out of 5
Was this helpful?
Rated 5 out of 5
Review posted


I loved this product.Its the best feeling in the world.i would definitely recommend it to anyone who needs calmness.

Improved Mood
Rated 5 out of 5
Enhanced Sense Of Wellbeing
Rated 5 out of 5
Reduced Stress
Rated 5 out of 5
Was this helpful?

Frequently Asked Questions

What is Serotonin Brain Food™?

Serotonin Brain Food™ is the first all-natural supplement designed to optimize levels of the neurotransmitter Serotonin.

What is Serotonin?

Serotonin is one of the brain’s most important neurotransmitters. Commonly considered the “happy molecule” serotonin is mainly associated with feelings of happiness, positive mood, mental calmness, and emotional balance.

When should I take Serotonin Brain Food™​?

You should take 2-3 capsules to support a positive mood, during situations of stress or irritability, or as directed by a healthcare practitioner.

Are there any side effects with Serotonin Brain Food?

You are NOT ingesting the neurotransmitter directly. Like all of our Brain Foods, Serotonin Brain Food™ contains the vitamins, minerals, and amino acids that are involved in the metabolism of that respective neurotransmitter. You are not directly ingesting or manipulating that neurotransmitter. By providing your body the nutrients it needs to metabolize these neurotransmitters, it is able to achieve optimal levels naturally. This method of naturally finding optimal levels also removes the chance of down-regulation, so you can safely take our Brain Foods to achieve and maintain optimal levels of Serotonin for long-term use.

What is Serotonin's function?

Serotonin functions in many areas throughout the body, most notably in the central nervous system for mood support, and in the gastrointestinal tract for appetite regulation. 

Serotonin was initially found to influence blood vessel constriction, but since the recent popularity of antidepressants like serotonin reuptake inhibitors (SSRIs) we’ve learned that serotonin functions as the brain’s primary “mood equalizer,” regulating mood, memory, social behavior, anxiety, sleep, and learning ability.

How do you increase Serotonin naturally?

Based on the scientific evidence there are 4 best ways to increase serotonin levels naturally: daily exposure to sunlight, positive thinking and mindfulness, exercise, and diet. 

When trying to increase serotonin levels naturally, the best first step is to ensure you deliver the essential vitamins, minerals, and nutrients your body and mind need to support peak serotonin production. 

Serotonin Brain Food™ contains the science-proven raw materials the brain needs to support optimal serotonin synthesis. These include tryptophan, B vitamins, magnesium, and zinc.

What is Serotonin Syndrome?

Serotonin Syndrome is a group of symptoms that can occur from certain medications or drugs that act on the serotonin pathway, increasing serotonin levels to extremely high amounts. Examples include SSRI’s, SNRI’s, TCAs, and MAOIs.

Symptoms range from mild to severe and include high body temperature, agitation, tremor, sweating, dilated pupils, increased reflexes and diarrhea.

Initial treatment consists of discontinuing medications that may be contributing.

The link between low serotonin and mood

Serotonin is the main neurotransmitter responsible for feelings of happiness and relaxation.

Lower levels of serotonin (serotonin deficiency) are linked with poor mood, depression, and anxiety.

When serotonin levels are at a healthy balance, we are more likely to feel happy, positive, and relaxed in all situations.

For this reason, serotonin is considered a "mood regulator,' directly linking your emotional well-being with the amount of serotonin present in the brain.

Low Serotonin and trouble sleeping

Serotonin is a calming neurotransmitter and if you have low levels, you may experience sleep disruptions and sleep disorders such as insomnia. 

Stress is a major contributing factor to low serotonin, which can result in a cycle of disrupted sleep, and mood disturbances like depression, anxiety, or fatigue.

What Natural Stacks work well with Serotonin Brain Food?

All Natural Stacks are compatible with Serotonin Brain Food.

For greater calm: GABA Brain Food for calmness during the day and anxiety relief.

For motivation and a positive mood: Dopamine Brain Food can be taken with Serotonin for an added dose of motivation and mental drive in addition to a positive mood. 

For an uplifting mood and productivity: CILTEP to feel more focused, productive, and upbeat during the day.

Citations & References

1. Young SN. The role of serotonin in human mood and social interaction. Insight from altered tryptophan levels. Pharmacol Biochem Behav. 2002 Apr;71(4):857-65.

2. Homberg JR. Serotonergic modulation of conditioned fear. Scientifica (Cairo). 2012;2012:821549. doi: 10.6064/2012/821549. Epub 2012 Oct 9.

3. Piszczek L., et al. Front Behav Neurosci. 2015 Feb 24;9:48. doi: 10.3389/fnbeh.2015.00048. eCollection 2015.

4. Kim JJ.,et al. 5-HT7 receptor signaling: Front Behav Neurosci. 2014 Dec 11;8:396. doi: 10.3389/fnbeh.2014.00396. eCollection 2014

5. Eric Noreen, et al. The effects of an acute dose of Rhodiola rosea on exercise performance and cognitive function. Journal of the International Society of Sports Nutrition. 20096(Suppl 1):P14. DOI: 10.1186/1550-2783-6-S1-P14. Published: 31 July 2009

6. Panossian A, Hambardzumyan M, Hovhanissyan A, Wikman G. The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-activated Protein Kinase, Nitric Oxide and Cortisol. Drug Target Insights. 2007;2:39-54.

7. Janet Best, et al. Theoretical Biology and Medical Modelling. 20107:34. DOI:10.1186/1742-4682-7-34. Published: 19 August 2010

8. INAGAWA, K., HIRAOKA, T., KOHDA, T., YAMADERA, W. and TAKAHASHI, M. (2006), Subjective effects of glycine ingestion before bedtime on sleep quality. Sleep and Biological Rhythms, 4: 75–77. doi:10.1111/j.1479-8425.2006.00193.

9. Singh M1, Das RR.Cochrane Database Syst Rev. 2011 Feb 16;(2):CD001364. doi: 10.1002/14651858.CD001364.pub3.

10. Mao JJ. Rhodiola rosea: A randomized placebo-controlled trial. Phytomedicine. 2015 Mar 15;22(3):394-9.

11. Phytother Res. 2014 Dec;28(12):1861-6. doi: 10.1002/ptr.5215. Epub 2014 Aug 22.

12. Molecules. 2015 May 11;20(5):8409-28. doi: 10.3390/molecules20058409.

13. Richard DM, Dawes MA, Mathias CW, Acheson A, Hill-Kapturczak N, Dougherty DM. L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Indications. International Journal of Tryptophan Research : IJTR. 2009;2:45-60.

14. Simon N. Young. Review article: The effect of raising and lowering tryptophan levels on human mood and social behaviour. Phil. Trans. R. Soc. B 2013 368 20110375; DOI: 10.1098/rstb.2011.0375. Published 25 February 2013

15. Anthony A. Sauve. NAD+ and Vitamin B3: Metabolism. Journal of Pharmacology and Experimental Therapeutics March 1, 2008, 324 (3) 883-893; DOI:

16. Cantó C, Houtkooper RH, Pirinen E, et al. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism. Cell metabolism. 2012;15(6):838-847. doi:10.1016/j.cmet.2012.04.022.

17. Samuel A.J. Trammell, et. al. Nicotinamide. Scientific Reports 6, Article number: 26933 (2016) doi:10.1038/srep26933

18. Devita Surjana, Gary M. Halliday, and Diona L. Damian. Review Article. Role of Nicotinamide in DNA. Journal of Nucleic Acids. Volume 2010 (2010), Article ID 157591, 13 pages.

19. Prasad AS. Zinc: Its Role in Human Health. Frontiers in Nutrition. 2014;1:14. doi:10.3389/fnut.2014.00014.

20. Robert A DiSilvestro and Melinda Swan. Comparison of Four Commercially Available Zinc Supplements for Performance in a Zinc Tolerance Test.

21. Swaminathan R. Magnesium Metabolism. The Clinical Biochemist Reviews. 2003;24(2):47-66.

22. Rosanoff A, Weaver CM, Rude RK. Suboptimal magnesium status in the United States: Nutr Rev. 2012 Mar;70(3):153-64. doi: 10.1111/j.1753-4887.2011.00465.x. Epub 2012 Feb 15.

23. Abbasi, B., Kimiagar, M., Sadeghniiat, K., Shirazi, M. M., Hedayati, M., & Rashidkhani, B. (2012). The effect of magnesium supplementation on primary insomnia in elderly: a double blind placebo-controlled clinical trial. Journal of Research in Medical Sciences, 17(12).

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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