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MycoMIND™ - Brain Cell Optimizer

For Cognitive Support
Rated 4.8 out of 5
52 Ratings
Regular price $39.95 List price



  • For Natural Cognitive Support
  • Maintain Healthy Brain Cells
  • Helps Combat Oxidative Stress

Maintain Healthy Brain Cells

MycoMIND can help grow new neurons which are the foundation to all mental tasks.

Support your overall brain health with MycoMINDs' natural antioxidant increasing formula.

MycoMIND helps combat oxidative stress and promotes healthy function of your Mitochondria.

Mind Your Mind

Help your brain age gracefully with MycoMIND.

MycoMIND is THE essential daily nootropic for feeding a healthy brain.

Made with Lions Mane Mushrooms which are shown to have many benefits to our brain including enhanced cognitive function, cell longevity, and scavenging free radicals.

How It Works

MycoMIND™ is a brain cell optimizer designed to promote Nerve Growth Factor and Mitochondrial Biogenesis.

Research suggests that the natural compounds in MycoMIND™ can grow new neurons and mitochondria, the foundation of all mental tasks. It’s the most essential daily nootropic.

  • Maintains healthy brain cells †
  • Promotes healthy mitochondrial function & biogenesis †
  • Supports graceful brain aging †
  • Helps combat oxidative stress †

This natural formula combines Organic Lion’s Mane mushroom extract with BioPQQ™ to support as many healthy brain cells as possible.

MycoMind™ contains natural ingredients that work synergistically to highlight the unique benefits of medicinal mushrooms. 

In this case that mushroom is Lion’s Mane. With only two ingredients, MycoMind™ supports cellular energy production in the brain, it confers neuroprotective properties related to the growth and health of new brain cells, and it supports overall brain health by increasing antioxidant status.

Lion’s Mane Mushroom

The original discovery of Lion’s Mane’s ability to increase Nerve Growth Factor (NGF) occurred in 1991 and is credited to Japanese scientists, Dr. Kawagishi. This discovery presented a massive paradigm shift in the way science looks at brain cells. No longer a finite number that decreases over our lifespan, entire fields of scientific research have since been devoted to maintaining - even increasing - brain cell counts for enhanced cognitive function and longevity.

Since that time, numerous studies have confirmed that this naturally occurring mushroom contains active compounds that stimulate NGF synthesis in human cells and promotes neurite outgrowth via activation of the JNK pathway (Jun amino-terminal kinase) This was proven in vivo. When they fed mice with Lions Mane powder there was an increase in the level of NGF mRNA expression in the hippocampus. [3,4]

A study published in the September 2014 edition of the International Journal of Molecular Science confirmed that Lion’s Mane contains a compound known as Erinacine A that effectively scavenges free radicals, inhibiting inflammation and helps repair injured brain and nerve cells. [5]

Based on a 2010 study published in Biomedical Research, Lion’s Mane seems to decrease anxiety and depression symptoms. [6]

According to a 2008 Japanese study, Lion’s Mane seems to halt and reverse (increased score on cognitive function scale) cognitive decline in 50-80 year old Japanese men and women who suffered from mild cognitive impairment. The effect weren’t permanent and the scores declined after 4 weeks of stopping the ingestion of Lion’s Mane. [7]


Pyrroloquinoline quinone, or PQQ for short, is a coenzyme that was discovered in 1979. PQQ is involved in many of the body’s natural metabolic processes and PQQ supplementation has been shown in studies to provide neuroprotective activity, anti-oxidative activity, and mitochondrial biogenesis.

Our source, BioPQQ is the industry leader for pyrroloquinoline quinone. Simply put, PQQ helps us create new mitochondria. [8]

In recent years, a substantial body of evidence has underscored the importance of mitochondrial function in maintaining energy balance, minimizing oxidative stress and promoting longevity. Mitochondrial function has been examined in many aspects, including metabolic, neural and age-related conditions. PQQ deficiency decreases the size, number and function of mitochondria in rodents, and supplementation reverses these effects.[9,10,11]

Supplementation with PQQ has been shown to improve memory and reasoning, while more studies indicate that PQQ offers neuro-protective properties via reduction of oxidative damage. In a randomized, double-blind study of 71 middle aged individuals, PQQ supplementation over 12 weeks significantly improved short term memory and demonstrated the ability to prevent memory loss. [12,13,14]

In 2012, Japanese researchers performed the first human study examining the effect of BioPQQ on stress, fatigue, and sleep. They concluded that supplementing with PQQ improved sleep, leading to reduced negative mental states, relief of fatigue and rise of positive mood. Other important conclusions from this study were that “mood also was improved by diminishing feelings of fatigue, and improved measures of appetite, sleep, pain and obsession with no adverse effects.” [15]

A 2016 study examining the impact of BioPQQ using near-infrared spectrometry (NIRS) found that cerebral blood flow in the prefrontal cortex was increased by the administration of PQQ. “The results suggest that PQQ can prevent reduction of brain function in aged persons, especially in attention and working memory.” [16]



The fruiting body of Lion’s Mane mushroom has been used in Japan for thousands of years for its nootropic effects on the brain. In recent years, western science has confirmed this mushroom’s neuroprotective properties and role in supporting higher-level cognitive function.


BioPQQ™ is the purest and most potent source of PQQ, a vitamin-like polyphenol with exceptional antioxidant properties and cellular modulating properties known to promote mitochondrial health, growth and function.

Read More About Pyrroloquinoline Quinone (BioPQQ™)

Suggested Use

Take a serving of 2 capsules 1 to 2 times per day for brain health and mental sharpness, or as directed by a healthcare practitioner.

U.S.A. manufactured in a cGMP facility. Natural Stacks proudly uses only the highest quality ingredients.

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Open Source

Most companies use "proprietary blends" so they don't have to tell you the amount of each ingredient in their formulas. At Natural Stacks we believe it's your right to know exactly what you're putting into your body. We proudly publish our innovative formulas and ingredient suppliers in an open source format.

Learn About Our Commitment To Transparency

The Myco™ Series

MycoBOOST™ - Full-Body Vitality

MycoBOOST™ - Full-Body Vitality


Yerba Mate and Cordyceps mushroom work to support energy production at the cellular level to increase physical performance and mental endurance.

Learn More


Support the body’s immune response to help combat viruses, bacteria, and other harmful pathogens.

Learn More

100% Happiness Guarantee

If for whatever reason you're unsatisfied with your Natural Stacks supplements, you can keep the full bottle on us and we'll refund your money. Anything after the first bottle, we'll ask that you return for a refund.

User Reviews

average rating 4.8 out of 5
Based on 52 ratings
  • 5 Stars
    44 Reviews
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    7 Reviews
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    1 Review
100% of reviewers would recommend this product to a friend
Improved Memory Function
Rated 4 out of 5
Increased Clarity
Rated 4 out of 5
37 Reviews
Rated 5 out of 5
Review posted

Improved Brain Function

I've been using MycoMind for 4 months and it has significantly improved my mental clarity. I have Lyme disease and Lion's Mane is recommended to support neurological issues. My brain fog has largely dissipated in the 4 months I've been using this product.

Improved Memory Function
Rated 5 out of 5
Increased Clarity
Rated 5 out of 5
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Rated 5 out of 5
Review posted

The Truth

As someone that has had (5) five strokes and I'm only 60, finding a supplement that actually works after wasting money on other supplements that did nothing, was a thrill. I'm looking forward to trying more.

Victor Morrill

Improved Memory Function
Rated 3 out of 5
Increased Clarity
Rated 3 out of 5
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Rated 5 out of 5
Review posted

This product turns on the lights

This product really helps keep me alert and mentally energized.

Improved Memory Function
Rated 5 out of 5
Increased Clarity
Rated 5 out of 5
Was this helpful?
Rated 5 out of 5
Review posted

Premium quality & high potency product!

The source founder Jeff Chilton of NAMMEX, that produces these extracts is the de facto industry leader in the field of mushrooms, with over 30years experience and having played a part in founding the mushroom supplement industry as we know it. These extracts feature a naturally grown high potency product that is probably the #1 highest quality product in the industry. Natural Stacks brings to the market an unparalleled high potency extract supplement, that is well worth your attention. Check out the Nov 1 Optimal Performance Podcast titled "Medicinal Mushrooms: NAMMEX Founder Jeff Chilton Exposes Industry Lies, Mycelium on Grain..."

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Rated 5 out of 5
Review posted

Charges me Up

I have been reading about PQQ so it was a matter of time before I gave MycoMind a shot. It works for me - gives me clean sustained energy throughout the day. I workout early morning so I don't yet know impact on exercise but I'll probably experiment with that too. Very happy with the first few days of use

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Citations & References

1. Kawagishi, H. Lion’s Mane: The Anti-Dementia Effect of Lion's Mane Mushroom and it’s Clinical Application. Townsend Letter for Doctors and Patients. APRIL 2004

2. Mori K. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.Phytother Res. 2009 Mar;23(3):367-72. doi: 10.1002/ptr.2634.

3. Mori K. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008 Sep;31(9):1727-32.

4. Lai PL. Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54.

5. Lee K-F, Chen J-H, Teng C-C, et al. Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine. International Journal of Molecular Sciences. 2014;15(9):15073-15089. doi:10.3390/ijms150915073.

6. Nagano M. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7.

7. Mori K. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.Phytother Res. 2009 Mar;23(3):367-72. doi: 10.1002/ptr.2634.

8. Chowanadisai W. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 1;285(1):142-52. doi: 10.1074/jbc.M109.030130. Epub 2009 Oct 27.

9. Stites T, Storms D, Bauerly K, Mah J, et al. Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice. J Nutr. 2006;136(2):390-6.

10. Bauerly KA, Storms DH, Harris CB, Hajizadeh S, et al. Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat. Biochim Biophys Acta. 2006;1760(11):1741-8.

11. Zhu BQ, Simonis U, Cecchini G, Zhou HZ, et al. Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. J Cardiovasc Pharmacol Ther. 2006;11(2):119-28.

12. He B. The roles of PI3K/Akt pathway in proliferation of Schwann cells promoted by pyrroloquinoline quinone. Zhonghua Zheng Xing Wai Ke Za Zhi. 2010 Jan;26(1):53-6.

13. Ohwada K, Takeda H, Yamazaki M, Isogai H, et al. Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats. J Clin Biochem Nutr. 2008;42:29-34]

14. Nakano M, Ubukata K, Yamamoto T, Yamaguchi H. Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. FOOD Style 21 2009;13(7):50-53.

15. Nakano, M. Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep. Functional Foods in Health and Disease 2012, 2(8):307-324 Page 307 of 324

16. Itoh, Y. Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions. Adv Exp Med Biol. 2016;876:319-25.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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