The Underconsumed and Underappreciated Brain Nutrient [The Stack 017]

G’day Stackers,

This week’s edition of The Stack heeds the headliner: choline

This essential nutrient donates to brain development, nerve function, muscle movement, energy, and metabolism. 

It helps in the process of methylation, which is a big part of detoxification and DNA. It’s also required for the formation of the neurotransmitter, acetylcholine

You can consider it a “brain food” found in foods such as eggs, beef, salmon, soy, chicken, mushrooms, and potatoes. 

Check out this week’s catch: how choline prevents cannabis damage, may reduce the risk of dementia, and how it can change an ischemic brain.

Choline may offset cannabis use damage during pregnancy

Maternal marijuana use can damage the fetal brain. A new study featured in Healthline found that consuming choline may help offset damage from cannabis use during pregnancy. 

  • Researchers studied 201 pregnant women and their newborns.
    • 60 mothers did not use marijuana
    • 16% only used it at conception
    • 8% used it the first few weeks after conception but stopped by 10 weeks
    • 15% continued to use it until term
    • Newborns were evaluated one month after birth and three months after birth
  • The longer a mother uses marijuana through pregnancy, the more serious self-regulation issues (attention and social function problems) the child may encounter later in life.
  • One-month-old infants who’d been exposed to marijuana after 10 weeks gestation had decreased central nervous system inhibition. At three months the infants had lower self-regulation scores
  • The defictits were not as present in the infants whose mothers had higher gestational choline levels in the second trimester. 
    • The infants of mothers with higher choline levels had higher attention spans and were more attached and cuddly.

Dietary choline associated with reduced risk of dementia

A new study by featured in ScienceDaily showed that dietary intake of phosphatidylcholine is associated with a reduced risk of dementia. 

  • Researchers analyzed about 2,500 Finnish men (age 42 to 60) from the Kuopio Ischaemic Heart Disease Risk Factor Study on their dietary and lifestyle habits.
  • Four years after the study onset, about 500 men completed tests measuring their memory and cognitive processing. During the follow-up, 337 men developed dementia. 
  • Results showed that the risk of dementia was 28% lower in men with the highest intake of phosphatidylcholine (key sources including eggs and meat), when compared to men with the lowest intake. 
    • Men with the highest intake of dietary phosphatidylcholine also excelled in tests measuring their memory and linguistic abilities.

B-Vitamin and choline changes the ischemic brain

A study published in the Journal of Young Investigators examined how recovery following stroke is dependent on several factors, including neuroplasticity (the ability of the brain to change) and to determine how nutrients (folic acid and choline with the goal of decreasing homocysteine) can influence this.

  • One month old male mice were placed on either a control diet. The supplemented diet contained higher levels of folic acid, riboflavin, vitamin B12, and choline. 
  • Neuroplasticity was assessed by comparing levels of brain-derived neurotrophic factor (BDNF) and growth differentiation factor II (GDF-II) in a mouse with ischemia. 
  • After ischemic damage, it was reported that the mice who received the supplemental diet had increased levels of BDNF compared to control mice. 
    • Results also indicated a trend for increased GDF-II in the supplemental diet mice, however, results were not significantly significant. 
  • Combined with previous results, this study suggests that supplementation with folic acid, vitamin B12, riboflavin, and choline may promote post-stroke neuroplasticity.

Natural Stacks habitué

Ben is an entrepreneur who works with other high level entrepreneurs and business owners. His goal is to help them perform at their highest. 

He started using Natural Stacks to help with this goal and his experience has been…

“UNBELIEVABLE. I recommend them to every person I interact with whenever they mention anything in regards to their performance. Need clearer thinking? Natural Stacks. Need less stress? Natural Stacks. Need better sleep? Natural Stacks. Need all day energy? Natural Stacks. Tell 'em Ben sent ya :)”

Natural Stacks helped give him, “clearer and more POWERFUL thinking. I have to think all day and solve problems all day. Natural Stacks has allowed me to maximize my brain's potential, get better results, with ZERO dangerous side effects.” 

Ben raves that he’s significantly less stressed and sleeps much better. Taking Natural Stacks helps him hit the gym harder. 

“Thank you Natural Stacks :) My life has improved drastically because of you."

Awe thanks Ben (blush) we feel the same about you :) 

Acetylcholine Brain Food™

Acetylcholine Brain Food™ is designed to promote the production of acetylcholine, a neurotransmitter essential to mental processing. 

To make acetylcholine, the brain needs two elements: an acetyl group and a choline molecule. 

Research suggests that the natural compounds in Acetylcholine Brain Food™ are associated with memory and cognitive function.

Acetylcholine Brain Food™ can give you:

  • Improved attention to detail
  • Better mental clarity
  • Faster thinking
  • Cuts through brain fog

With increased clarity, you’ll notice the small details and be more present in work and personal experiences.

What else we're Stacking…

Mental illness isn't a major risk factor for gun violence, but here's what is [NBC News]

Schizophrenia: Genes related to circadian rhythms may be disrupted [Medical News Today]

Why Short-Term Stress and Anxiety Can Actually Be Good for You [Healthline]

Study Finds 3 Cups of Coffee May Trigger Migraine [Healthline]

Focus boosting drugs not worth the risks, studies warn [Medical News Today]

Physical fitness may help prevent depression, anxiety [Medical News Today]

30 Minutes of Daily Exercise May Help Reduce Alzheimer’s Symptoms [Healthline]

Being a pessimist or an optimist may affect your sleep [Medical News Today]

Your brain food specialists,

-Natural Stacks 


NEUROFUEL™ is the original CILTEP® formula for enhanced focus, deep concentration and improved memory. 

The premium natural ingredients work as fuel for your neurotransmitters, supporting greater ... MORE

$ 29.95
Should You Start Harnessing Hibernation?

Should You Start Harnessing Hibernation?

Hi Snug as a Bug in a Rug Stackers, Hibernation is a way for animals...

Stay Healthy for the Holidays [The Stack 030]

Stay Healthy for the Holidays [The Stack 030]

Compliments of the Season Stackers, Holidays have a way of unleashing our inner consumer-monster.   From...

Boost Your Immunity and Beat Seasonal Bugs [The Stack 029]

Boost Your Immunity and Beat Seasonal Bugs [The Stack 029]

Season’s Greetings Stackers, The season of Santa, snowflakes, and sniffles is upon us.  As you’re...