Season’s Greetings Stackers,
The season of Santa, snowflakes, and sniffles is upon us.
As you’re making your list and checking it twice, your immune system is being oh so nice (to you).
This week’s edition of The Stack delivers good tidings about your immunity and the many gifts it gives.
Brain immune cells may protect against OCD and anxiety
Medical News Today presented the findings from a recent Cell Reports study conducted on mice, suggesting that microglia (immune cells inside the brain) are associated with anxiety and obsessive-compulsive disorder (OCD).
About one-third of all microglia in adult mice brains come from precursors of Hoxb8 - a protein that can alter cell behavior by turning gene function on or off.
- The experiments in this study showed that inactivating Hoxb8 microglia in mice caused OCD behaviors (such as overgrooming) and that activating Hoxb8 microglia can stop the compulsive behavior.
- Researchers also saw that female sex hormones can worsen the OCD and anxiety which comes from the dysfunctional Hoxb8-lineage microglia.
- Symptoms were worse in female mice when compared to male mice.
- Female mice displayed anxiety (seen by dilated pupils) under stress conditions.
- In the study, researchers were able to link anxiety to a dysfunction of one type of microglia and female sex hormones.
Sleep allows immune cells to do maintenance on the brain
Researchers looked into mice microglia (immune cells that can help “service” the brain) of mice and how they do their repair at night.
- Researchers anesthetized mice and compared awake mice to sleeping mice.
- They examined norepinephrine, a chemical messenger that helps regulate sleep-wake cycles.
- During sleep, norepinephrine levels in the brain are typically low.
- Researchers observed that when norepinephrine becomes elevated, the microglia turn off.
- Suggesting microglia may work more efficiently during sleep versus when awake.
- This means that during states of arousal or wakefulness, the immune cells could not respond as intended and could not “maintenance” the brain cell connections.
Do stress-related disorders raise the risk of infections?
According to a new BMJ study presented in Medical News Today, having a diagnosis of post-traumatic stress disorder (PTSD) or other stress-related condition may increase the risk of getting certain infections.
- Researchers examined infection rates in 144,919 people with a diagnosis of PTSD and other stress disorders between 1987 and 2013.
- 184,612 siblings of people living with a diagnosis of a stress-related disorder were compared with 1,4449.190 matched individuals without a stress condition.
- The analysis showed that stress-related disorders were associated with an increased risk of life threatening infections (such as sepsis, endocarditis, meningitis).
- The results showed a 63% higher risk of meningitis among those with stress-related disorders and 57% higher risk of endocarditis, compared to siblings who did not have stress-related conditions.
- It was also noted that substance use disorders further increased the risk and, in contrast, using selective serotonin re-uptake inhibitors in the first year of diagnosis of the stress disorder lowered the risk.
Vitamin C + Zinc Glycinate
Vitamin C is essential for immune function and antioxidant support.
It scavenges free radicals in the body, removing these unstable molecules as a protective mechanism for optimal health and wellness.
Zinc is crucial for supporting your body’s immune system and neurological function. Zinc Glycinate is chelated to improve absorption and bioavailability.
Natural Stacks Vitamin C + Zinc Glycinate contains a combination of Vitamin C and a fully chelated Zinc Glycinate to boost immunity and neurological function.
A 2012 meta analysis on two double-blind, randomized, placebo-controlled trials found that “Vitamin C plus Zinc was significantly more efficient than placebo at reducing rhinorrhoea (runny nose)” 
Natural Stacks Vitamin C + Zinc Glycinate contains synergistic antioxidants to provide your body with a high level of protection against the stresses of modern life.
Natural Stacks habitué
Hanako is on the pursuit of knowledge and truth with a wide variety of:
- Experiences: working towards a master’s degree in data science, data analytics, modeling, and engineering
- Education: including biology, chemistry, biological anthropology, psychology, neuroscience, EMT, massage therapy, computer programing, and relational databases.
Hanako has managed to conquer these amazing life experiences all while suffering from a plethora of mental and physical health concerns, including autoimmune disorder, chronic pain, and fatigue.
Hanako discovered the Natural Stacks products helped tremendously...
“I have never experienced such quick and strong effects. I notice a drastic difference in how I feel and how I think when I'm using their products and when I don't. I have not found any other brand or company that comes close to this experience.”
Coming from a strong research and science background, Hanako trusts the effectiveness of the products.
“It has made having health goals a possibility. Prior to finding Natural Stacks, I had come to accept chronic pain and physical/mental struggles to be a daily reality. I did not have goals of improvement, greater activity and exercise, or even a stronger immune system. The combination of a great team of doctors with the use of several Natural Stacks products has allowed me to have hope for greater health and quality of life.”
What else we're Stacking…
How do gut microbes help mice extinguish fear memories? [Medical News Today]
Only half of U.S. children get enough sleep: why that’s a serious problem [Healthline]
Lifestyle is a threat to gut bacteria: Ötzi proves It, study shows [Science Daily]
How a high salt diet may lead to cognitive decline [Medical News Today]
Sunday sadness is real. Here's how to battle the pre-workweek blues [CNN Health]
Does sunlight change our gut microbiome? [Medical News Today]
Good tidings we bring to you and your brain,